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Synthetic Accesses to 3/5-pyrazole Carboxylic Acids

Abstract : This review attempts to sum up all the synthetic accesses to 3/5-pyrazole carboxylic acids or esters published, or patented, in the last 120 years. Many of them have demonstrated their robustness as well as quite large scopes. However, a majority are relying on the regioselectivity of reactions such as ketones deprotonations,cyclocondensations or [2+3] cycloadditions. For this reason, the preparation of original 3/5-carboxypyrazoles featuring a structure departing from the inherent regioselectivity of these synthetic accesses could be problematic. Moreover, a large scale synthesis of some 3/5-carboxypyrazoles could be a real challenge. It is thus reasonable to forecast that even more synthetic methodologies should be reported in the future in attempts to meet such requirements.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00515847
Contributor : Yves Janin <>
Submitted on : Wednesday, September 8, 2010 - 10:00:33 AM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

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Yves L. Janin. Synthetic Accesses to 3/5-pyrazole Carboxylic Acids. Mini-Reviews in Organic Chemistry, Bentham Science Publishers, 2010, 7, pp.314-323. ⟨10.2174/157019310792246364⟩. ⟨pasteur-00515847⟩

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