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Article Dans Une Revue Trends in Immunology Année : 2007

From induced to programmed lymphoid tissues: the long road to preempt pathogens.

Gérard Eberl

Résumé

In mammalian fetuses, ontogeny dictates the development of secondary lymphoid tissues, the spleen, the lymph nodes and the Peyer's patches. In adults, commensals, infectious microbes and inflammation induce the formation of small reversible lymphoid tissues resembling lymph nodes or Peyer's patches. Crucial to lymphoid-tissue genesis is lymphotoxin-beta receptor-mediated activation of inflammatory effectors and structural chemokines. This pathway might have existed since the advent of the vertebrate lymphocyte system to organize local adaptive immunity in response to microbes; however, it only operates in the absence of microbes in mammals, resulting in the development of secondary lymphoid tissues and in preempting pathogens.

Domaines

Immunologie

Dates et versions

pasteur-00509617 , version 1 (13-08-2010)

Identifiants

Citer

Gérard Eberl. From induced to programmed lymphoid tissues: the long road to preempt pathogens.. Trends in Immunology, 2007, 28 (10), pp.423-8. ⟨10.1016/j.it.2007.07.009⟩. ⟨pasteur-00509617⟩
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