From induced to programmed lymphoid tissues: the long road to preempt pathogens. - Archive ouverte HAL Access content directly
Journal Articles Trends in Immunology Year : 2007

From induced to programmed lymphoid tissues: the long road to preempt pathogens.

(1)
1
Gérard Eberl

Abstract

In mammalian fetuses, ontogeny dictates the development of secondary lymphoid tissues, the spleen, the lymph nodes and the Peyer's patches. In adults, commensals, infectious microbes and inflammation induce the formation of small reversible lymphoid tissues resembling lymph nodes or Peyer's patches. Crucial to lymphoid-tissue genesis is lymphotoxin-beta receptor-mediated activation of inflammatory effectors and structural chemokines. This pathway might have existed since the advent of the vertebrate lymphocyte system to organize local adaptive immunity in response to microbes; however, it only operates in the absence of microbes in mammals, resulting in the development of secondary lymphoid tissues and in preempting pathogens.

Dates and versions

pasteur-00509617 , version 1 (13-08-2010)

Identifiers

Cite

Gérard Eberl. From induced to programmed lymphoid tissues: the long road to preempt pathogens.. Trends in Immunology, 2007, 28 (10), pp.423-8. ⟨10.1016/j.it.2007.07.009⟩. ⟨pasteur-00509617⟩
19 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More