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Journal articles
Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria.
Abstract : Glycosylphosphatidylinositol (GPI) membrane anchors of Plasmodium falciparum surface proteins are thought to be important factors contributing to malaria pathogenesis, and anti-GPI antibodies have been suggested to provide protection by neutralizing the toxic activity of GPIs. In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen were evaluated in two distinct groups of 70 patients each, who were hospitalized with malaria. Anti-GPI IgGs were significantly lower in patients hospitalized with confirmed cerebral malaria compared to those with mild malaria (P < 0.01) but did not discriminate for fatal outcome. In contrast, a specific marker of the anti-parasite immunity, as monitored by the anti-MSP1p19 IgG response, was similar in both cerebral and mild malaria individuals, although it was significantly lower in a subgroup with fatal outcomes. These results are consistent with a potential anti-toxin role for anti-GPI antibodies associated with protection against cerebral malaria.
Cited literature [26 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00494272
Contributor : Ronald Perraut Connect in order to contact the contributor
Submitted on : Tuesday, June 22, 2010 - 3:39:08 PM
Last modification on : Monday, November 22, 2021 - 5:46:02 PM
Long-term archiving on: : Friday, September 24, 2010 - 5:48:54 PM
Contributor : Ronald Perraut Connect in order to contact the contributor
Submitted on : Tuesday, June 22, 2010 - 3:39:08 PM
Last modification on : Monday, November 22, 2021 - 5:46:02 PM
Long-term archiving on: : Friday, September 24, 2010 - 5:48:54 PM
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NP_paper_IPD.pdf
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