Physiology of the Prion Protein, Physiological Reviews, vol.88, issue.2, pp.673-728, 2008. ,
DOI : 10.1152/physrev.00007.2007
Mammalian Prion Biology, Cell, vol.116, issue.2, pp.313-327, 2004. ,
DOI : 10.1016/S0092-8674(03)01031-6
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene, Nature, vol.380, issue.6574, pp.528-531, 1996. ,
DOI : 10.1038/380528a0
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel, Journal of Molecular Biology, vol.292, issue.4, pp.797-817, 1999. ,
DOI : 10.1006/jmbi.1999.3108
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain, The EMBO Journal, vol.20, issue.4, pp.694-702, 2001. ,
DOI : 10.1093/emboj/20.4.694
Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene, Cellular and Molecular Neurobiology, vol.20, issue.5, pp.553-567, 2000. ,
DOI : 10.1023/A:1007059827541
Physiological Expression of the Gene for PrP-Like Protein, PrPLP/Dpl, by Brain Endothelial Cells and its Ectopic Expression in Neurons of PrP-Deficient Mice Ataxic Due to Purkinje Cell Degeneration, The American Journal of Pathology, vol.157, issue.5, pp.1447-1452, 2000. ,
DOI : 10.1016/S0002-9440(10)64782-7
The prion protein family: Diversity, rivalry, and dysfunction, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1772, issue.6, pp.654-672, 2007. ,
DOI : 10.1016/j.bbadis.2007.05.001
Two different neurodegenerative diseases caused by proteins with similar structures, Proceedings of the National Academy of Sciences, vol.98, issue.5, pp.2352-2357, 2001. ,
DOI : 10.1073/pnas.051627998
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp 0/0 mice predisposed to Purkinje cell loss, J. Biol. Chem, vol.275, pp.26834-26841, 2000. ,
Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia, The EMBO Journal, vol.22, issue.12, pp.3095-3101, 2003. ,
DOI : 10.1093/emboj/cdg285
A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination, Lab. Invest, vol.79, pp.689-697, 1999. ,
Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions, Cell, vol.93, issue.2, pp.203-214, 1998. ,
DOI : 10.1016/S0092-8674(00)81572-X
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105???125, The EMBO Journal, vol.95, issue.2, pp.548-558, 2007. ,
DOI : 10.1038/sj.emboj.7601507
Lethal recessive myelin toxicity of prion protein lacking its central domain, The EMBO Journal, vol.21, issue.2, pp.538-547, 2007. ,
DOI : 10.1038/sj.emboj.7601510
Interaction of Doppel with the full-length laminin receptor precursor protein, Archives of Biochemistry and Biophysics, vol.428, issue.2, pp.165-169, 2004. ,
DOI : 10.1016/j.abb.2004.06.003
Prion protein paralog doppel protein interacts with ?-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration Analysis of doppel protein toxicity, PLoS One Mol. Cell. Neurosci, vol.4, issue.23, pp.144-155, 2003. ,
do not share the same membrane microenvironment, FEBS Letters, vol.21, issue.1-3, pp.85-88, 2002. ,
DOI : 10.1016/S0014-5793(02)03430-0
Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes, Neuroscience, vol.141, issue.3, pp.1375-1388, 2006. ,
DOI : 10.1016/j.neuroscience.2006.04.068
The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1689, issue.1, pp.1-5, 2004. ,
DOI : 10.1016/j.bbadis.2004.02.003
Absence of interaction between doppel and GFAP, Grb2, PrPc proteins in human tumor astrocytic cells, Anticancer Res, vol.25, pp.4369-4374, 2005. ,
Human Doppel and prion protein share common membrane microdomains and internalization pathways, The International Journal of Biochemistry & Cell Biology, vol.36, issue.10, pp.2016-2031, 2004. ,
DOI : 10.1016/j.biocel.2004.03.002
Rafts defined: a report on the Keystone symposium on lipid rafts and cell function, The Journal of Lipid Research, vol.47, issue.7, pp.1597-1598, 2006. ,
DOI : 10.1194/jlr.E600002-JLR200
The prion protein and lipid rafts (Review), Molecular Membrane Biology, vol.165, issue.1, pp.89-99, 2006. ,
DOI : 10.1042/bj3160923
Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-?? proteins, Seminars in Cell & Developmental Biology, vol.18, issue.5, pp.638-648, 2007. ,
DOI : 10.1016/j.semcdb.2007.07.008
The highways and byways of prion protein trafficking, Trends in Cell Biology, vol.15, issue.2, pp.102-111, 2005. ,
DOI : 10.1016/j.tcb.2004.12.002
URL : https://hal.archives-ouvertes.fr/pasteur-00167019
A Pathogenic PrP Mutation and Doppel Interfere with Polarized Sorting of the Prion Protein, Journal of Biological Chemistry, vol.280, issue.7, pp.5137-5140, 2005. ,
DOI : 10.1074/jbc.C400560200
PrPC Is Sorted to the Basolateral Membrane of Epithelial Cells Independently of its Association with Rafts, Traffic, vol.107, issue.11, pp.810-821, 2002. ,
DOI : 10.1034/j.1600-0854.2002.31106.x
PrPC Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its Cellular Conformation, Molecular Biology of the Cell, vol.15, issue.9, pp.4031-4042, 2004. ,
DOI : 10.1091/mbc.E03-05-0271
URL : https://hal.archives-ouvertes.fr/pasteur-00167023
Dissecting the molecular function of reggie/flotillin proteins, European Journal of Cell Biology, vol.86, issue.9, pp.525-532, 2007. ,
DOI : 10.1016/j.ejcb.2007.03.003
Cell Surface Biotinylation Techniques, Cell Biology: A Laboratory Handbook, pp.185-192, 1994. ,
DOI : 10.1016/B978-0-12-164717-9.50028-3
The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism, Molecular Pharmacology, vol.70, issue.4, pp.1298-1306, 2006. ,
DOI : 10.1124/mol.106.025601
Glycosphingolipid clusters and the sorting of GPI-anchored proteins in epithelial cells, Braz. J. Med. Biol. Res, vol.27, pp.317-322, 1994. ,
Oligomerization Is a Specific Requirement for Apical Sorting of Glycosyl-Phosphatidylinositol-Anchored Proteins but Not for Non-Raft-Associated Apical Proteins, Traffic, vol.140, issue.3, pp.251-258, 2007. ,
DOI : 10.1111/j.1600-0854.2006.00522.x
URL : https://hal.archives-ouvertes.fr/pasteur-00166611
Overexpression of the Doppel protein in acute myeloid leukaemias and myelodysplastic syndromes, British Journal of Haematology, vol.83, issue.6, pp.877-884, 2005. ,
DOI : 10.1016/j.bbrc.2003.12.020
Glycosylation in Cellular Mechanisms of Health and Disease, Cell, vol.126, issue.5, pp.855-867, 2006. ,
DOI : 10.1016/j.cell.2006.08.019
Rapid protein-folding assay using green fluorescent protein, Nature Biotechnology, vol.17, issue.7, pp.691-695, 1999. ,
DOI : 10.1038/10904
Membrane domains of intestinal epithelial cells: distribution of Na+,K+- ATPase and the membrane skeleton in adult rat intestine during fetal development and after epithelial isolation, The Journal of Cell Biology, vol.109, issue.5, pp.2129-2138, 1989. ,
DOI : 10.1083/jcb.109.5.2129
PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells, Cellular and Molecular Life Sciences, vol.61, issue.16, pp.2092-2099, 2004. ,
DOI : 10.1007/s00018-004-4193-x
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines, European Journal of Neuroscience, vol.11, issue.12, pp.2063-2072, 2005. ,
DOI : 10.1111/j.1460-9568.2005.04049.x
URL : https://hal.archives-ouvertes.fr/hal-00078687
PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction, The FASEB Journal, vol.18, pp.1731-1733, 2004. ,
DOI : 10.1096/fj.04-2150fje
Regulation of embryonic cell adhesion by the prion protein Lipid rafts, protein scaffolds, and neurologic disease, PLoS Biol. E. E. Neurology, vol.7, issue.69, pp.1635-1639, 2007. ,
Lipid rafts in health and disease, Biology of the Cell, vol.27, issue.(23), pp.129-140, 2007. ,
DOI : 10.1042/BC20060051
Possible Neuroprotective Mechanism of Human Neuroglobin, Annals of the New York Academy of Sciences, vol.91, issue.1, pp.220-230, 2005. ,
DOI : 10.1111/j.1749-6632.2005.tb00028.x
Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology, Neuroscience Letters, vol.290, issue.2, pp.93-96, 2000. ,
DOI : 10.1016/S0304-3940(00)01334-3