In untreated HIV-1-infected children, PBMC-associated HIV DNA levels and cell free HIV RNA levels are correlated to distinct T lymphocyte populations. - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Journal of Acquired Immune Deficiency Syndromes - JAIDS Année : 2010

In untreated HIV-1-infected children, PBMC-associated HIV DNA levels and cell free HIV RNA levels are correlated to distinct T lymphocyte populations.

Résumé

Background: Clinical studies support biologically independent roles of cell-free HIV particles and HIV-infected cells in disease progression. The associations between the level of infected cells and immune markers have been poorly studied, particularly in perinatally infected children. Objective: We tested the hypothesis that independent roles of cell-free virus and infected cells in HIV pathogenesis should be revealed by different associations between each of them and specific immune markers. Methods: Levels of HIV RNA and DNA, HIV-specific CD8 T lymphocytes, activated and naïve/memory T lymphocytes were determined in 44 untreated HIV-1-infected children. Pearson’s partial correlation coefficients were used to assess associations between the variables. Results: Here we provide new information, by showing a direct correlation between the percentages of CD4+HLA-DR+ lymphocytes and HIV DNA levels. Furthermore, higher HIV-specific CD8 T lymphocyte frequencies were associated with lower HIV DNA levels. In contrast, CD8+38+ lymphocytes and memory CD4 lymphocytes were correlated only to the HIV RNA level. All correlations were independent of age and CD4 depletion. Conclusion: Several immune markers were correlated to either the HIV RNA or the HIV DNA level, but never to both of them, supporting the concept that cell-free virus and infected cells play different roles in HIV-1 immunopathogenesis.
Fichier principal
Vignette du fichier
Buseyne-QAIH5716-Revised-HAL.pdf (138.35 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

pasteur-01418102 , version 1 (16-12-2016)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Daniel Scott-Algara, Christine Rouzioux, Stéphane Blanche, Marianne Burgard, Céline Didier, et al.. In untreated HIV-1-infected children, PBMC-associated HIV DNA levels and cell free HIV RNA levels are correlated to distinct T lymphocyte populations.. Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2010, 53 (5), pp.553-563. ⟨10.1097/QAI.0b013e3181cf060f⟩. ⟨pasteur-01418102⟩

Collections

PASTEUR CNRS
380 Consultations
267 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More