Experimental infection of squirrel monkeys with nipah virus.

Philippe Marianneau (1) , Vanessa Guillaume (2) , Thong Wong (3) , Munisamy Badmanathan (3) , Ren Yih Looi (3) , Severine Murri (1) , Philippe Loth (1) , Noel Tordo (1) , Fabian T. Wild (2) , Branka Horvat (2) , Hugues Contamin (1)

1 UBIVE - Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections
2 Virologie humaine
3 UM - University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie]

We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.

Domaines: Microbiologie et Parasitologie

Philippe Marianneau, Vanessa Guillaume, Thong Wong, Munisamy Badmanathan, Ren Yih Looi, et al.. Experimental infection of squirrel monkeys with nipah virus.. Emerging Infectious Diseases, 2010, 16 (3), pp.507-10. ⟨10.3201/eid1603.091346⟩. ⟨pasteur-00488658⟩