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CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.

Abstract : TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. Thus, TLR9 signals can regulate B lymphopoiesis in vivo.
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Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Friday, May 7, 2010 - 4:01:39 PM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM

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Ana Inés Lalanne, Ignacio Moraga, Yi Hao, João Pedro Pereira, Nuno L. Alves, et al.. CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.. Journal of Immunology, 2010, epub ahead of print. ⟨10.4049/jimmunol.0903854⟩. ⟨pasteur-00481956⟩



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