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Journal articles
Hepatitis B virus (HBV)-derived DRB1*0101-restricted CD4 T-cell epitopes help in the development of HBV-specific CD8+ T cells in vivo.
Abstract : We previously identified two HLA-DRB1*0101-restricted epitopes in hepatitis B virus (HBV) X protein (HBx) and in HBV envelope proteins (preS2). To evaluated their help in the development of CD8+ T-cell responses, mice transgenic for human class I and class II HLA molecules were immunized with HBV-T helper constructs. The preS2 epitope favored a well-balanced response with CD4+ and CD8+ T cells producing IFN-gamma, IL-2 and TNF-alpha. The response was focused on CD8+ T cells with the HBx epitope. Fine characterization of helper activities may meet clinical needs in terms of enhancing the potency of preventive or therapeutic polyepitope vaccines.
Cited literature [24 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00474284
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Submitted on : Monday, April 19, 2010 - 2:56:27 PM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM
Long-term archiving on: : Tuesday, September 28, 2010 - 12:54:13 PM
Contributor : Ana de Casas Connect in order to contact the contributor
Submitted on : Monday, April 19, 2010 - 2:56:27 PM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM
Long-term archiving on: : Tuesday, September 28, 2010 - 12:54:13 PM
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Bayard_et_al._Vaccine.pdf
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