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Journal articles
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.
Abstract : Human T cell leukemia virus type 1 (HTLV-1) is a lymphotropic retrovirus whose cell-to-cell transmission requires cell contacts. HTLV-1-infected T lymphocytes form 'virological synapses', but the mechanism of HTLV-1 transmission remains poorly understood. We show here that HTLV-1-infected T lymphocytes transiently store viral particles as carbohydrate-rich extracellular assemblies that are held together and attached to the cell surface by virally-induced extracellular matrix components, including collagen and agrin, and cellular linker proteins, such as tetherin and galectin-3. Extracellular viral assemblies rapidly adhere to other cells upon cell contact, allowing virus spread and infection of target cells. Their removal strongly reduces the ability of HTLV-1-producing cells to infect target cells. Our findings unveil a novel virus transmission mechanism based on the generation of extracellular viral particle assemblies whose structure, composition and function resemble those of bacterial biofilms. HTLV-1 biofilm-like structures represent a major route for virus transmission from cell to cell.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00460124
Contributor : Mireille Gau <>
Submitted on : Thursday, September 24, 2020 - 9:26:12 AM
Last modification on : Friday, October 16, 2020 - 3:10:36 PM
Contributor : Mireille Gau <>
Submitted on : Thursday, September 24, 2020 - 9:26:12 AM
Last modification on : Friday, October 16, 2020 - 3:10:36 PM