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Journal articles
Hepatitis C virus infection protein network.
B. de Chassey
1, 2
V. Navratil
2, 3
L. Tafforeau
1, 2
M. S. Hiet
1, 2
A. Aublin-Gex
1, 2
S. Agaugué
1, 2
G. Meiffren
1, 2
F. Pradezynski
1, 2
B. F. Faria
1, 2
T. Chantier
1, 2
M. Le Breton
1, 2
J. Pellet
1, 2
N. Davoust
1, 2
P. E. Mangeot
1, 2
A. Chaboud
2, 4
F. Penin
2, 4
Y. Jacob
5
P. O. Vidalain
6
M. Vidal
7
P. André
1, 2, 8
C. Rabourdin-Combe
1, 2
V. Lotteau
2, 8, *
*
Corresponding author
B. F. Faria 1, 2
Author
T. Chantier 1, 2
Author
M. Le Breton 1, 2
Author IdHAL : mathieulebreton ORCID : https://orcid.org/0000-0002-2947-7457
J. Pellet 1, 2
Author
Y. Jacob 5
Author
P. O. Vidalain 6
Author IdHAL : pierre-olivier-vidalain ORCID : https://orcid.org/0000-0003-3082-7407
M. Vidal 7
Author
P. André 1, 2, 8
Author
C. Rabourdin-Combe 1, 2
Author
V. Lotteau 2, 8
Correspondent author
1
I2V - Immunité infection vaccination (CERVI 21, avenue tony garnier 69365 LYON CEDEX 07 - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- IFR128 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U851 (101, rue de Tolbiac, 75013 Paris - France)
2
BLG - BioSciences Lyon-Gerland (Tour INSERM-CERVI 21 Avenue Tony Garnier 69365 LYON CEDEX 07 - France)
- ENS Lyon - École normale supérieure - Lyon (15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07 - France)
- INRA - Institut National de la Recherche Agronomique (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : IFR128 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : IFR128 (France)
3
RPC - Rétrovirus et Pathologie Comparée (50, avenue Tony Garnier 69366 Lyon Cedex 07 - France)
- INRA - Institut National de la Recherche Agronomique : UR0754 (France)
- EPHE - École pratique des hautes études (4-14 Rue Ferrus, 75014 Paris - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- ENVL - Ecole Nationale Vétérinaire de Lyon (France)
4
IBCP - Institut de biologie et chimie des protéines [Lyon] (7 Passage du Vercors 69367 LYON CEDEX 07 - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5086 (France)
5
Génétique, Papillomavirus et Cancer Humain (25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
6
Génomique Virale et Vaccination (25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : URA3015 (France)
7
CCSB - Center for Cancer Systems Biology (450 Brookline Ave., Boston, MA 02215 - United States)
- Dana-Farber Cancer Institute [Boston] (450 Brookline Ave. Boston, MA 02215 - United States)
- Department of Cancer Biology (France)
8
Laboratoire de virologie (Lyon - France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
- Hôpital de la Croix-Rousse [CHU - HCL] (103 Grande Rue de la Croix-Rousse
69004 Lyon - France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
Abstract : A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein-protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFbeta pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-00456466
Contributor : Mireille Gau Connect in order to contact the contributor
Submitted on : Monday, February 15, 2010 - 3:50:50 PM
Last modification on : Wednesday, November 17, 2021 - 5:28:01 PM
Long-term archiving on: : Friday, June 18, 2010 - 6:34:55 PM
Contributor : Mireille Gau Connect in order to contact the contributor
Submitted on : Monday, February 15, 2010 - 3:50:50 PM
Last modification on : Wednesday, November 17, 2021 - 5:28:01 PM
Long-term archiving on: : Friday, June 18, 2010 - 6:34:55 PM
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msb200866.pdf
Publisher files allowed on an open archive
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-00456466, version 1
- DOI : 10.1038/msb.2008.66
- PRODINRA : 148195
- PUBMED : 18985028
- WOS : 000263287800436
Citation
B. de Chassey, V. Navratil, L. Tafforeau, M. S. Hiet, A. Aublin-Gex, et al.. Hepatitis C virus infection protein network.. Molecular Systems Biology, EMBO Press, 2008, 4 (230), pp.230. ⟨10.1038/msb.2008.66⟩. ⟨pasteur-00456466⟩
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