J. Orange and Z. Ballas, Natural killer cells in human health and disease, Clinical Immunology, vol.118, issue.1, pp.1-10, 2006.
DOI : 10.1016/j.clim.2005.10.011

E. Vivier, E. Tomasello, M. Baratin, T. Walzer, and S. Ugolini, Functions of natural killer cells, Nature Immunology, vol.178, issue.5, pp.503-510, 2008.
DOI : 10.1073/pnas.050588297

URL : https://hal.archives-ouvertes.fr/hal-00294184

A. Moretta, Natural killer cells and dendritic cells: rendezvous in abused tissues, Nature Reviews Immunology, vol.23, issue.12, pp.957-964, 2002.
DOI : 10.1038/nri956

S. Wieland and F. Chisari, Stealth and Cunning: Hepatitis B and Hepatitis C Viruses, Journal of Virology, vol.79, issue.15, pp.9369-9380, 2005.
DOI : 10.1128/JVI.79.15.9369-9380.2005

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181548

P. Fisicaro, C. Valdatta, C. Boni, M. Massari, and C. Mori, Early kinetics of innate and adaptive immune responses during hepatitis B virus infection, Gut, vol.58, issue.7, pp.974-982, 2009.
DOI : 10.1136/gut.2008.163600

S. Pol and M. Michel, Therapeutic vaccination in chronic hepatitis B virus carriers, Expert Review of Vaccines, vol.5, issue.5, pp.707-716, 2006.
DOI : 10.1586/14760584.5.5.707

M. Mancini-bourgine, H. Fontaine, D. Scott-algara, S. Pol, and C. Brechot, Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers, Hepatology, vol.1, issue.Suppl 1, pp.874-882, 2004.
DOI : 10.1002/hep.20408

O. Akbari, N. Panjwani, S. Garcia, R. Tascon, and D. Lowrie, DNA Vaccination: ???Transfection and Activation of Dendritic Cells as Key Events for Immunity, The Journal of Experimental Medicine, vol.8, issue.1, pp.169-178, 1999.
DOI : 10.1016/S1074-7613(00)80256-3

A. Krieg, CpG motifs: the active ingredient in bacterial extracts?, Nature Medicine, vol.9, issue.7, pp.831-835, 2003.
DOI : 10.1038/nm0703-831

S. Gurunathan, D. Klinman, and R. Seder, DNA Vaccines: Immunology, Application, and Optimization, Annual Review of Immunology, vol.18, issue.1, pp.927-974, 2000.
DOI : 10.1146/annurev.immunol.18.1.927

Z. Ballas, W. Rasmussen, and A. Krieg, Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA, J Immunol, vol.157, pp.1840-1845, 1996.

M. Michel, H. Davis, M. Schleef, M. Mancini, and P. Tiollais, DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans., Proceedings of the National Academy of Sciences, vol.92, issue.12, pp.5307-5311, 1995.
DOI : 10.1073/pnas.92.12.5307

M. Mancini, M. Hadchouel, H. Davis, R. Whalen, and P. Tiollais, DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state., Proceedings of the National Academy of Sciences, vol.93, issue.22, pp.12496-12501, 1996.
DOI : 10.1073/pnas.93.22.12496

D. Loirat, F. Lemonnier, and M. Michel, Multiepitopic HLA-A*0201-Restricted Immune Response Against Hepatitis B Surface Antigen After DNA-Based Immunization, The Journal of Immunology, vol.165, issue.8, pp.4748-4755, 2000.
DOI : 10.4049/jimmunol.165.8.4748

H. Davis, M. Mccluskie, J. Gerin, and R. Purcell, DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines., Proceedings of the National Academy of Sciences, vol.93, issue.14, pp.7213-7218, 1996.
DOI : 10.1073/pnas.93.14.7213

B. Rehermann and N. Naoumov, Immunological techniques in viral hepatitis, Journal of Hepatology, vol.46, issue.3, pp.508-520, 2007.
DOI : 10.1016/j.jhep.2007.01.002

M. Mancini-bourgine, H. Fontaine, C. Brechot, S. Pol, and M. Michel, Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers, Vaccine, vol.24, issue.21, pp.4482-4489, 2006.
DOI : 10.1016/j.vaccine.2005.08.013

G. Webster, S. Reignat, M. Maini, S. Whalley, and G. Ogg, Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms, Hepatology, vol.30, issue.5, pp.1117-1124, 2000.
DOI : 10.1053/jhep.2000.19324

A. Moretta, E. Marcenaro, S. Parolini, G. Ferlazzo, and L. Moretta, NK cells at the interface between innate and adaptive immunity, Cell Death and Differentiation, vol.178, issue.2, pp.226-233, 2008.
DOI : 10.1182/blood-2004-10-4035

A. Krug, A. French, W. Barchet, J. Fischer, and A. Dzionek, TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function, Immunity, vol.21, issue.1, pp.107-119, 2004.
DOI : 10.1016/j.immuni.2004.06.007

S. Sivori, M. Falco, D. Chiesa, M. Carlomagno, S. Vitale et al., CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells, Proceedings of the National Academy of Sciences, vol.101, issue.27, pp.10116-10121, 2004.
DOI : 10.1073/pnas.0403744101

M. Degli-esposti and M. Smyth, Close encounters of different kinds: Dendritic cells and NK cells take centre stage, Nature Reviews Immunology, vol.166, issue.2, pp.112-124, 2005.
DOI : 10.1038/nri1549

S. Wieland, R. Thimme, R. Purcell, and F. Chisari, Genomic analysis of the host response to hepatitis B virus infection, Proceedings of the National Academy of Sciences, vol.101, issue.17, pp.6669-6674, 2004.
DOI : 10.1073/pnas.0401771101

C. Dunn, D. Peppa, P. Khanna, G. Nebbia, and M. Jones, Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection, Gastroenterology, vol.137, issue.4, pp.1287-300, 2009.
DOI : 10.1053/j.gastro.2009.06.054

B. Oliviero, S. Varchetta, E. Paudice, G. Michelone, and M. Zaramella, Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections, Gastroenterology, vol.137, issue.3, pp.1151-60, 2009.
DOI : 10.1053/j.gastro.2009.05.047

URL : http://hdl.handle.net/2434/223217

M. Hokland and P. Kuppen, Natural killer cells: from ???disturbing??? background to central players of immune responses, Molecular Immunology, vol.42, issue.4, pp.381-383, 2005.
DOI : 10.1016/j.molimm.2004.07.016

L. Chlewicki, C. Velikovsky, V. Balakrishnan, R. Mariuzza, and V. Kumar, Molecular Basis of the Dual Functions of 2B4 (CD244), The Journal of Immunology, vol.180, issue.12, pp.8159-8167, 2008.
DOI : 10.4049/jimmunol.180.12.8159

P. Aguilar, C. Mathieu, G. Clerc, G. Ethevenot, and M. Fajraoui, Modulation of Natural Killer (NK) Receptors on NK (CD3???/CD56+), T (CD3+/CD56???) and NKT-like (CD3+/CD56+) Cells after Heart Transplantation, NKT-like (CD3+/CD56+) cells after heart transplantation, pp.200-205, 2006.
DOI : 10.1016/j.healun.2005.08.007

C. Dunn, M. Brunetto, G. Reynolds, T. Christophides, and P. Kennedy, Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell???mediated liver damage, The Journal of Experimental Medicine, vol.266, issue.3, pp.667-680, 2007.
DOI : 10.1084/jem.189.2.441

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137916

M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, and T. Miyagi, Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection, The Journal of Immunology, vol.173, issue.10, pp.6072-6081, 2004.
DOI : 10.4049/jimmunol.173.10.6072

M. Jinushi, T. Takehara, T. Tatsumi, S. Yamaguchi, and R. Sakamori, T cells with PD-1-dependent regulatory activities, Immunology, vol.439, issue.1, pp.73-82, 2007.
DOI : 10.1111/j.1365-2567.2006.02479.x

S. Burgess, K. Maasho, M. Masilamani, S. Narayanan, and F. Borrego, The NKG2D receptor: immunobiology and clinical implications, Immunologic Research, vol.6, issue.Pt 2, pp.18-34, 2008.
DOI : 10.1007/s12026-007-0060-9

H. Zhou, Y. Luo, J. Lo, C. Kaplan, and M. Mizutani, DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor, Proceedings of the National Academy of Sciences, vol.102, issue.31, pp.10846-10851, 2005.
DOI : 10.1073/pnas.0502208102

H. Zhou, Y. Luo, C. Kaplan, J. Kruger, and S. Lee, A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the NKG2D receptor, Blood, vol.107, issue.8, pp.3251-3257, 2006.
DOI : 10.1182/blood-2005-10-4231

Y. Chen, H. Wei, R. Sun, Z. Dong, and J. Zhang, Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells, Hepatology, vol.201, issue.3, pp.706-715, 2007.
DOI : 10.1002/hep.21872

A. Poggi, P. Costa, E. Tomasello, and L. Moretta, IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A- mediated down-regulation of NK cell activation, European Journal of Immunology, vol.25, issue.5, pp.1611-1616, 1998.
DOI : 10.1002/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6

L. Azzoni, O. Zatsepina, B. Abebe, I. Bennett, and P. Kanakaraj, Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells, J Immunol, vol.161, pp.3493-3500, 1998.

P. Krebs, M. Barnes, K. Lampe, K. Whitley, and K. Bahjat, NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses, Blood, vol.113, issue.26, pp.6593-6602, 2009.
DOI : 10.1182/blood-2009-01-201467

M. Caligiuri, Human natural killer cells, Blood, vol.112, issue.3, pp.461-469, 2008.
DOI : 10.1182/blood-2007-09-077438

URL : https://hal.archives-ouvertes.fr/hal-00431858

H. Virgin, E. Wherry, and R. Ahmed, Redefining Chronic Viral Infection, Journal of End-to-End-testing, vol.138, issue.1, pp.30-50, 2009.
DOI : 10.1016/S9999-9994(09)20378-3

URL : http://dx.doi.org/10.1016/j.cell.2009.06.036

C. Chan, D. Andrews, and M. Smyth, Can NK cells be a therapeutic target in human diseases?, European Journal of Immunology, vol.24, issue.11, pp.2964-2968, 2008.
DOI : 10.1002/eji.200838764