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Journal articles
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
Cedric Auffray
1
Darin K. Fogg
1
Emilie Narni-Mancinelli
2
Brigitte Senechal
1
Celine Trouillet
1, 3
Noah Saederup
4
Julia Leemput
5
Karine Bigot
5
Laura Campisi
2
Marc Abitbol
5
Thierry Molina
1
Israel Charo
4
David A. Hume
6
Ana Cumano
7
Gregoire Lauvau
2
Frederic Geissmann
1, 3, *
*
Corresponding author
Cedric Auffray 1
Author
Darin K. Fogg 1
Author
Emilie Narni-Mancinelli 2
Author
Brigitte Senechal 1
Author
David A. Hume 6
Author
Ana Cumano 7
Author
Gregoire Lauvau 2
Author
Frederic Geissmann 1, 3
Correspondent author
1
Système des phagocytes mononucléés et immunopathologie (Hopital Necker Enfants Malades
149 rue de Sevres
75743 PARIS CEDEX 15 - France)
- UPD5 - Université Paris Descartes - Paris 5 : EA 219 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
2
Immunologie des maladies infectieuses allergiques et autoimmunes (IPMC Sophia Antipolis 660 rue des Lucioles, 06560 Valbonne - France)
- UNS - Université Nice Sophia Antipolis (... - 2019) (Parc Valrose - BP 2135 - 06103 Nice cedex 2 - France)
- COMUE UCA - COMUE Université Côte d'Azur (2015 - 2019) (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U924 (101, rue de Tolbiac, 75013 Paris - France)
3
Centre for Cellular and Molecular Biology of Inflammation (SE1 9RT London - United Kingdom)
- King‘s College London (Strand Campus, London WC2R 2LS - United Kingdom)
4
Gladstone Institute of Cardiovascular Disease (San Francisco CA 94158 - United States)
- UCSF - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)
- University of California (United States)
5
Centre d'étude et de recherche thérapeutiques en ophtalmologie (France)
- UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
6
The Roslin Institute and Royal (Dick) School of Veterinary Studies (EH25 9PS Roslin Scotland - United Kingdom)
- University of Edinburgh (Old College South Bridge Edinburgh EH8 9YL - United Kingdom)
7
Développement des Lymphocytes (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U668 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00428989
Contributor : Marie-Christine Vougny <>
Submitted on : Monday, November 2, 2009 - 11:32:05 AM
Last modification on : Wednesday, November 25, 2020 - 2:52:07 PM
Long-term archiving on: : Thursday, June 17, 2010 - 6:47:39 PM
Contributor : Marie-Christine Vougny <>
Submitted on : Monday, November 2, 2009 - 11:32:05 AM
Last modification on : Wednesday, November 25, 2020 - 2:52:07 PM
Long-term archiving on: : Thursday, June 17, 2010 - 6:47:39 PM
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JEM.pdf
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Identifiers
- HAL Id : pasteur-00428989, version 1
- DOI : 10.1084/jem.20081385
- PUBMED : 19273628
Collections
PASTEUR | UNICE | UNIV-PARIS5 | USPC | UNIV-COTEDAZUR | UNIV-PARIS
Citation
Cedric Auffray, Darin K. Fogg, Emilie Narni-Mancinelli, Brigitte Senechal, Celine Trouillet, et al.. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.. Journal of Experimental Medicine, Rockefeller University Press, 2009, 206 (3), pp.595-606. ⟨10.1084/jem.20081385⟩. ⟨pasteur-00428989⟩
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