L. Guidotti and F. Chisari, IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS, Annual Review of Pathology: Mechanisms of Disease, vol.1, issue.1, pp.23-61, 2006.
DOI : 10.1146/annurev.pathol.1.110304.100230

M. Mancini-bourgine, H. Fontaine, D. Scott-algara, S. Pol, C. Brechot et al., Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers, Hepatology, vol.1, issue.Suppl 1, pp.874-882, 2004.
DOI : 10.1002/hep.20408

S. Pol and M. Michel, Therapeutic vaccination in chronic hepatitis B virus carriers, Expert Review of Vaccines, vol.5, issue.5, pp.707-716, 2006.
DOI : 10.1586/14760584.5.5.707

S. Ha, E. West, K. Araki, K. Smith, and R. Ahmed, Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections, Immunological Reviews, vol.335, issue.1, pp.317-333, 2008.
DOI : 10.1111/j.1600-065X.2008.00638.x

F. Liu, Y. Song, and D. Liu, Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA, Gene Therapy, vol.6, issue.7, pp.1258-1266, 1999.
DOI : 10.1038/sj.gt.3300947

P. Yang, A. Althage, J. Chung, and F. Chisari, Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection, Proceedings of the National Academy of Sciences, vol.99, issue.21, pp.13825-13830, 2002.
DOI : 10.1073/pnas.202398599

A. Pajot, M. Michel, N. Fazilleau, V. Pancre, C. Auriault et al., -knockout mice, European Journal of Immunology, vol.6, issue.11, pp.3060-3069, 2004.
DOI : 10.1002/eji.200425463
URL : https://hal.archives-ouvertes.fr/jpa-00209784

M. Mancini, M. Hadchouel, H. Davis, R. Whalen, P. Tiollais et al., DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state., Proceedings of the National Academy of Sciences, vol.93, issue.22, pp.12496-12501, 1996.
DOI : 10.1073/pnas.93.22.12496

D. Loirat, M. Mancini-bourgine, J. Abastado, and M. Michel, HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection, International Immunology, vol.15, issue.10, pp.1125-1136, 2003.
DOI : 10.1093/intimm/dxg117

M. Michel, H. Davis, M. Schleef, M. Mancini, P. Tiollais et al., DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans., Proceedings of the National Academy of Sciences, vol.92, issue.12, pp.5307-5311, 1995.
DOI : 10.1073/pnas.92.12.5307

R. Zhu, S. Diem, L. Araujo, A. Aumeunier, J. Denizeau et al., The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis, The Journal of Immunology, vol.178, issue.9, pp.5435-5442, 2007.
DOI : 10.4049/jimmunol.178.9.5435
URL : https://hal.archives-ouvertes.fr/inserm-00314236

M. Betts, J. Brenchley, D. Price, D. Rosa, S. Douek et al., Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation, Journal of Immunological Methods, vol.281, issue.1-2, pp.65-78, 2003.
DOI : 10.1016/S0022-1759(03)00265-5

M. Sells, A. Zelent, M. Shvartsman, and G. Acs, Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions, J Virol, vol.62, pp.2836-2844, 1988.

J. Alexander, J. Sidney, S. Southwood, J. Ruppert, C. Oseroff et al., Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides, Immunity, vol.1, issue.9, pp.751-761, 1994.
DOI : 10.1016/S1074-7613(94)80017-0

A. Bertoletti, S. Southwood, R. Chesnut, A. Sette, M. Falco et al., Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor, Hepatology, vol.26, issue.4, pp.1027-1034, 1997.
DOI : 10.1002/hep.510260435

C. Seeger and W. Mason, Hepatitis B Virus Biology, Microbiology and Molecular Biology Reviews, vol.64, issue.1, pp.51-68, 2000.
DOI : 10.1128/MMBR.64.1.51-68.2000

P. Scaglioni, M. Melegari, and J. Wands, Posttranscriptional regulation of hepatitis B virus replication by the precore protein, J Virol, vol.71, pp.345-353, 1997.

D. Loirat, F. Lemonnier, and M. Michel, Multiepitopic HLA-A*0201-Restricted Immune Response Against Hepatitis B Surface Antigen After DNA-Based Immunization, The Journal of Immunology, vol.165, issue.8, pp.4748-4755, 2000.
DOI : 10.4049/jimmunol.165.8.4748

J. Liu, B. Ewald, D. Lynch, A. Nanda, S. Sumida et al., Modulation of DNA Vaccine-Elicited CD8+ T-Lymphocyte Epitope Immunodominance Hierarchies, Journal of Virology, vol.80, issue.24, pp.11991-11997, 2006.
DOI : 10.1128/JVI.01348-06

M. Mancini, M. Hadchouel, P. Tiollais, and M. Michel, Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization, J Immunol, vol.161, pp.5564-5570, 1998.

A. Das, M. Hoare, N. Davies, A. Lopes, C. Dunn et al., Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection, The Journal of Experimental Medicine, vol.163, issue.9, pp.2111-2124, 2008.
DOI : 10.1128/JVI.79.14.8960-8968.2005

S. Gunther, N. Piwon, A. Jung, A. Iwanska, H. Schmitz et al., Enhanced Replication Contributes to Enrichment of Hepatitis B Virus with a Deletion in the Core Gene, Virology, vol.273, issue.2, pp.286-299, 2000.
DOI : 10.1006/viro.2000.0432

I. Crispe, Hepatic T cells and liver tolerance, Nature Reviews Immunology, vol.3, issue.1, pp.51-62, 2003.
DOI : 10.1038/nri981

P. Bertolino, Impaired function of dendritic cells translocating the liver sinusoids: A veto effect contributing to intrahepatic tolerance?, European Journal of Immunology, vol.34, issue.4, pp.938-941, 2008.
DOI : 10.1002/eji.200838296

N. Dikopoulos, I. Jomantaite, R. Schirmbeck, and J. Reimann, Specific, functional effector/memory CD8+ T cells are found in the liver post-vaccination, Journal of Hepatology, vol.39, issue.6, pp.910-917, 2003.
DOI : 10.1016/S0168-8278(03)00469-0

R. Keating, W. Yue, J. Rutigliano, J. So, E. Olivas et al., Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill, The Journal of Immunology, vol.178, issue.5, pp.2737-2745, 2007.
DOI : 10.4049/jimmunol.178.5.2737

V. Cavanaugh, L. Guidotti, and F. Chisari, Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice, J Virol, vol.72, pp.2630-2637, 1998.

V. Pasquetto, L. Guidotti, K. Kakimi, M. Tsuji, and F. Chisari, Host???Virus Interactions during Malaria Infection in Hepatitis B Virus Transgenic Mice, The Journal of Experimental Medicine, vol.83, issue.4, pp.529-536, 2000.
DOI : 10.1093/infdis/166.6.1465

S. Ladner, M. Otto, C. Barker, K. Zaifert, G. Wang et al., Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication, Antimicrob Agents Chemother, vol.41, pp.1715-1720, 1997.