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The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.

Abstract : Survival of peripheral CD8(+) T cells requires TCR interactions with peptide-MHC complexes (p-MHC). In the adult mouse, in the presence of homeostatic mechanisms that strictly control T cell numbers, it is likely that diverse T cell clones may compete for shared patterns of p-MHC. In the present study, we investigate whether the recognition of p-MHC overlaps between different T cell populations and what role does this process plays in the establishment of the peripheral T cell pools. Using an experimental strategy that follows the fate of adoptively transferred polyclonal T cells into RAG(0/0) or different TCR transgenic RAG(0/0) hosts, we demonstrate that T cells bearing different TCR specificities share identical TCR-specific requirements for survival and lymphopenia driven proliferation (LDP). This interclonal competition applies to both naive and activated/memory T cells and is partially determined by the clone size of the established/resident T cells. However, clonal competition with activated/memory resident T cells impacts differently on the fate of newly produced bone-marrow-derived T cells or adoptively transferred peripheral T cells. Overall, our findings indicate that p-MHC define multiple diverse resource niches that can be shared by T cells from different compartments.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00381857
Contributor : Marie-Christine Vougny <>
Submitted on : Wednesday, May 6, 2009 - 3:51:03 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM

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Catarina Leitão, António A Freitas, Sylvie Garcia. The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (9), pp.5232-9. ⟨10.4049/jimmunol.0804071⟩. ⟨pasteur-00381857⟩

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