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Journal articles
The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.
Abstract : Survival of peripheral CD8(+) T cells requires TCR interactions with peptide-MHC complexes (p-MHC). In the adult mouse, in the presence of homeostatic mechanisms that strictly control T cell numbers, it is likely that diverse T cell clones may compete for shared patterns of p-MHC. In the present study, we investigate whether the recognition of p-MHC overlaps between different T cell populations and what role does this process plays in the establishment of the peripheral T cell pools. Using an experimental strategy that follows the fate of adoptively transferred polyclonal T cells into RAG(0/0) or different TCR transgenic RAG(0/0) hosts, we demonstrate that T cells bearing different TCR specificities share identical TCR-specific requirements for survival and lymphopenia driven proliferation (LDP). This interclonal competition applies to both naive and activated/memory T cells and is partially determined by the clone size of the established/resident T cells. However, clonal competition with activated/memory resident T cells impacts differently on the fate of newly produced bone-marrow-derived T cells or adoptively transferred peripheral T cells. Overall, our findings indicate that p-MHC define multiple diverse resource niches that can be shared by T cells from different compartments.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00381857
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Wednesday, May 6, 2009 - 3:51:03 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:55 PM
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Wednesday, May 6, 2009 - 3:51:03 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:55 PM
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