Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 Season.

Adam Meijer (1, 2) , Angie Lackenby (3, 4) , Olav Hungnes (5) , Bruno Lina (3, 6) , Sylvie van Der Werf (3, 7) , Brunhilde Schweiger (8) , Matthias Opp (9) , John Paget (1) , Jan Van-De-Kassteele (2) , Alan Hay (3, 10) , Maria Zambon (3, 4) , On Behalf of The European Influenza Surveillance Scheme

1 Netherlands Institute for Health Services Research
2 RIVM - National Institute for Public Health and the Environment [Bilthoven]
3 European Surveillance Network for Vigilance against Viral Resistance
4 Health Protection Agency
5 NIPH - Norwegian Institute of Public Health [Oslo]
6 Centre National de Référence Virus Influenza (Région Sud)
7 Centre National de Référence de la Grippe (France Nord) - Centre Collaborateur de l'OMS Grippe et autres virus respiratoires (CNR - CCOMS)
8 RKI - Robert Koch Institute [Berlin]
9 LNS - Laboratoire National de Santé [Luxembourg]
10 World Health Organization Collaborating Centre Medical Research Council/National Institute of Medical Research

In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.

Domaines: Biochimie, Biologie Moléculaire

Adam Meijer, Angie Lackenby, Olav Hungnes, Bruno Lina, Sylvie van Der Werf, et al.. Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 Season.. Emerging Infectious Diseases, 2009, 15 (4), pp.552-60. ⟨10.3201/eid1504.181280⟩. ⟨pasteur-00379911⟩