C. Aiken, J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono, Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain, Cell, vol.76, issue.5, pp.853-864, 1994.
DOI : 10.1016/0092-8674(94)90360-3

F. Aniento, F. Gu, R. G. Parton, and J. Gruenberg, An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes, The Journal of Cell Biology, vol.133, issue.1, pp.29-41, 1996.
DOI : 10.1083/jcb.133.1.29

A. Bansal and L. M. Gierasch, The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation, Cell, vol.67, issue.6, pp.1195-1201, 1991.
DOI : 10.1016/0092-8674(91)90295-A

J. F. Bazan, Haemopoietic receptors and helical cytokines, Immunology Today, vol.11, pp.350-354, 1990.
DOI : 10.1016/0167-5699(90)90139-Z

A. Bothner-by, R. L. Stephens, and J. Lee, Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame, Journal of the American Chemical Society, vol.106, issue.3, pp.811-813, 1984.
DOI : 10.1021/ja00315a069

M. Braun, A. Waheed, and K. Figura, Lysosomal acid phosphatase is transported to lysosomes via the cell surface, EMBO (Eur. Mol. Biol. Organ.) J, vol.8, pp.3633-3640, 1989.

J. F. Collawn, M. Stangel, L. A. Kuhn, V. Esekogwu, S. Jing et al., Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis, Cell, vol.63, issue.5, pp.1061-1072, 1990.
DOI : 10.1016/0092-8674(90)90509-D

J. P. Disanto, A. Dautry-varsat, S. Certain, A. Fischer, G. De-saint et al., Interleukin-2 (IL-2) receptor ?? chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding, European Journal of Immunology, vol.10, issue.2, pp.475-479, 1994.
DOI : 10.1002/eji.1830240232

J. P. Disanto, F. Rieux-laucat, A. Dautry-varsat, A. Fischer, G. De-saint et al., Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells., Proc. Natl. Acad. Sci. USA, pp.9466-9470, 1994.
DOI : 10.1073/pnas.91.20.9466

V. Duprez and A. Dautry-varsat, Receptor mediated endocytosis of interleukin 2 in a human tumor T cell line: degradation of interleukin 2 and evidence for the absence of recycling of interleukin 2 receptors, J. Biol. Chem, vol.261, pp.15450-15454, 1986.

V. Duprez, V. Cornet, and A. Dautry-varsat, Down regulation of high affinity interleukin 2 receptors in a human tumor T cell line: IL2 increases the rate of surface receptor decay, J. Biol. Chem, vol.263, pp.12860-12865, 1988.

H. J. Dyson, M. Rance, R. A. Houghten, R. A. Lerner, and P. E. Wright, Folding of immunogenic peptide fragments of proteins in water solution, Journal of Molecular Biology, vol.201, issue.1, pp.161-200, 1988.
DOI : 10.1016/0022-2836(88)90446-9

W. Eberle, C. Sander, W. Klaus, B. Schmidt, K. Figura et al., The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a ?? turn, Cell, vol.67, issue.6, pp.1203-1209, 1991.
DOI : 10.1016/0092-8674(91)90296-B

S. A. Green, H. Setiadi, R. P. Mcever, and R. B. Kelly, The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes, The Journal of Cell Biology, vol.124, issue.4, pp.435-448, 1994.
DOI : 10.1083/jcb.124.4.435

C. Griesinger, G. Otting, K. Wüthrich, and R. R. Ernst, Clean TOCSY for proton spin system identification in macromolecules, Journal of the American Chemical Society, vol.110, issue.23, pp.7870-7872, 1988.
DOI : 10.1021/ja00231a044

E. Grote, J. C. Hao, M. K. Bennett, and R. B. Kelly, A targeting signal in VAMP regulating transport to synaptic vesicles, Cell, vol.81, issue.4, pp.581-589, 1995.
DOI : 10.1016/0092-8674(95)90079-9

J. Gruenberg and F. R. Maxfield, Membrane transport in the endocytic pathway, Current Opinion in Cell Biology, vol.7, issue.4, pp.552-563, 1995.
DOI : 10.1016/0955-0674(95)80013-1

S. H. Hansen, K. Sandvig, and B. Van-deurs, Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors, The Journal of Cell Biology, vol.123, issue.1, pp.89-97, 1993.
DOI : 10.1083/jcb.123.1.89

C. Harter and I. Mellman, Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane, The Journal of Cell Biology, vol.117, issue.2, pp.311-325, 1992.
DOI : 10.1083/jcb.117.2.311

A. Hémar and A. Dautry-varsat, Cyclosporin A inhibits the interleukin 2 receptor ?? chain gene transcription but not its cell surface expression: the ?? chain stability can explain this discrepancy, European Journal of Immunology, vol.168, issue.12, pp.2629-2635, 1990.
DOI : 10.1002/eji.1830201216

A. Hémar, M. Lieb, A. Subtil, J. P. Disanto, and A. Dautry-varsat, Endocytosis of the ?? chain of interleukin-2 receptor requires neither interleukin-2 nor the ?? chain, European Journal of Immunology, vol.168, issue.9, pp.1951-1955, 1994.
DOI : 10.1002/eji.1830240902

A. Hémar, A. Subtil, M. Lieb, E. Morelon, R. Hellio et al., Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains, The Journal of Cell Biology, vol.129, issue.1, pp.55-64, 1995.
DOI : 10.1083/jcb.129.1.55

S. Höning and W. Hunziker, Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells, The Journal of Cell Biology, vol.128, issue.3, pp.321-332, 1995.
DOI : 10.1083/jcb.128.3.321

Z. Huang, Y. Chen, and R. A. Nissenson, The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis, Journal of Biological Chemistry, vol.270, issue.1, pp.151-156, 1995.
DOI : 10.1074/jbc.270.1.151

W. Hunziker and H. J. Geuze, Intracellular trafficking of lysosomal membrane proteins, BioEssays, vol.130, issue.5, pp.379-389, 1996.
DOI : 10.1002/bies.950180508

S. Jing, T. Spencer, K. Miller, C. Hopkins, and I. S. Trowbridge, Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization, The Journal of Cell Biology, vol.110, issue.2, pp.283-294, 1990.
DOI : 10.1083/jcb.110.2.283

C. Lamaze and S. L. Schmid, The emergence of clathrin-independent pinocytic pathways, Current Opinion in Cell Biology, vol.7, issue.4, pp.573-580, 1995.
DOI : 10.1016/0955-0674(95)80015-8

F. Letourneur and R. D. Klausner, A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains, Cell, vol.69, issue.7, pp.1143-1157, 1992.
DOI : 10.1016/0092-8674(92)90636-Q
URL : https://hal.archives-ouvertes.fr/hal-00314003

S. Macura and R. R. Ernst, Elucidation of cross relaxation in liquids by two-dimensional N, M.R. spectroscopy. Mol. Phys, vol.41, pp.95-117, 1980.

A. Mallabiabarrena, M. A. Jiménez, M. Rico, and B. Alarcon, A tyrosine-containing motif mediates ER retention of CD3-and adopts a helix-turn structure, EMBO (Eur. Mol. Biol. Organ.) J, vol.14, pp.2257-2268, 1995.

M. S. Marks, P. A. Roche, E. Van-donselaar, L. Woodruff, P. J. Peters et al., A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments, The Journal of Cell Biology, vol.131, issue.2, pp.351-369, 1995.
DOI : 10.1083/jcb.131.2.351

P. M. Mathews, J. B. Martinie, and D. M. Fambrough, The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes, The Journal of Cell Biology, vol.118, issue.5, pp.1027-1040, 1992.
DOI : 10.1083/jcb.118.5.1027

S. Mayor, J. F. Presley, and F. R. Maxfield, Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process, The Journal of Cell Biology, vol.121, issue.6, pp.1257-1269, 1993.
DOI : 10.1083/jcb.121.6.1257

Y. Minami, T. Kono, T. Miyazaki, and T. Taniguchi, The IL-2 Receptor Complex: Its Structure, Function, and Target Genes, Annual Review of Immunology, vol.11, issue.1, pp.245-267, 1993.
DOI : 10.1146/annurev.iy.11.040193.001333

S. Minamoto, H. Mori, M. Hatakeyama, T. Kono, T. Doi et al., Characterization of the heterodimeric complex of human IL2 receptor chains reconstituted in a mouse fibroblast cell line, L929, J. Immunol, vol.145, pp.2177-2182, 1990.

A. Motta, B. Bremnes, M. A. Morelli, R. W. Frank, G. Saviano et al., Structure-Activity Relationship of the Leucine-based Sorting Motifs in the Cytosolic Tail of the Major Histocompatibility Complex-associated Invariant Chain, Journal of Biological Chemistry, vol.270, issue.45, pp.27165-27171, 1995.
DOI : 10.1074/jbc.270.45.27165

J. W. Nelson and N. R. Kallenbach, Stabilization of the ribonuclease S-peptide ??-helix by trifluoroethanol, Proteins: Structure, Function, and Genetics, vol.8, issue.3, pp.211-217, 1986.
DOI : 10.1002/prot.340010303

M. Noguchi, H. Yi, H. M. Rosenblatt, A. H. Filipovich, S. Adelstein et al., Interleukin-2 receptor ?? chain mutation results in X-linked severe combined immunodeficiency in humans, Cell, vol.73, issue.1, pp.147-157, 1993.
DOI : 10.1016/0092-8674(93)90167-O

C. G. Odorizzi, I. S. Trowbridge, L. Xue, C. Hopkins, C. D. Davis et al., Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment, The Journal of Cell Biology, vol.126, issue.2, pp.317-330, 1994.
DOI : 10.1083/jcb.126.2.317

S. Padmanabhan, S. Marqusee, T. Ridgeway, T. M. Laue, and R. L. Baldwin, Relative helix-forming tendencies of nonpolar amino acids, Nature, vol.344, issue.6263, pp.268-270, 1990.
DOI : 10.1038/344268a0

C. Peters, M. Braun, B. Weber, M. Wendland, B. Schmidt et al., Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes, EMBO (Eur. Mol. Biol. Organ.) J, vol.9, pp.3497-3506, 1990.

M. Rance, O. W. Sorensen, G. Bodenhausen, and G. Wagner, Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filtering, Biochemical and Biophysical Research Communications, vol.117, issue.2, pp.479-485, 1983.
DOI : 10.1016/0006-291X(83)91225-1
URL : https://hal.archives-ouvertes.fr/hal-00813137

M. S. Robinson, The role of clathrin, adaptors and dynamin in endocytosis, Current Opinion in Cell Biology, vol.6, issue.4, pp.538-544, 1994.
DOI : 10.1016/0955-0674(94)90074-4

M. S. Robinson, C. Watts, and M. Zerial, Membrane Dynamics in Endocytosis, Cell, vol.84, issue.1, pp.13-21, 1996.
DOI : 10.1016/S0092-8674(00)80988-5

J. Rohrer, A. Schweizer, D. Russell, and S. Kornfeld, The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane, The Journal of Cell Biology, vol.132, issue.4, pp.565-576, 1996.
DOI : 10.1083/jcb.132.4.565

L. A. Rubin, C. C. Kutman, M. E. Fritz, W. E. Biddison, B. Boutin et al., Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro, J. Immunol, vol.135, pp.3172-3177, 1985.

I. V. Sandoval and O. Bakke, Targeting of membrane proteins to endosomes and lysosomes, Trends in Cell Biology, vol.4, issue.8, pp.292-297, 1994.
DOI : 10.1016/0962-8924(94)90220-8

D. J. States, R. A. Haberkorn, and D. J. Ruben, A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants, Journal of Magnetic Resonance (1969), vol.48, issue.2, pp.286-292, 1982.
DOI : 10.1016/0022-2364(82)90279-7

A. Subtil, A. Hémar, and A. Dautry-varsat, Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited, Biology of the Cell, vol.84, issue.1-2, pp.3461-3468, 1994.
DOI : 10.1016/0248-4900(96)81369-4

K. Sugamura, H. Asao, M. Kondo, N. Tanaka, N. Ishii et al., THE INTERLEUKIN-2 RECEPTOR ?? CHAIN: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID, Annual Review of Immunology, vol.14, issue.1, pp.179-205, 1996.
DOI : 10.1146/annurev.immunol.14.1.179

R. Sutherland, D. Delia, C. Schneider, R. Newman, J. Kemshead et al., Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin., Proceedings of the National Academy of Sciences, vol.78, issue.7, pp.4515-4519, 1981.
DOI : 10.1073/pnas.78.7.4515

I. S. Trowbridge and C. R. Hopkins, Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway, Annual Review of Cell Biology, vol.9, issue.1, pp.129-161, 1993.
DOI : 10.1146/annurev.cb.09.110193.001021

S. Vijayasaradhi, Y. Xu, B. Bouchard, and A. N. Houghton, Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75, The Journal of Cell Biology, vol.130, issue.4, pp.807-820, 1995.
DOI : 10.1083/jcb.130.4.807

S. D. Voss, T. P. Leary, P. M. Sondel, and R. J. Robb, Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain., Proc. Natl. Acad. Sci. USA, pp.2428-2432, 1993.
DOI : 10.1073/pnas.90.6.2428

J. A. Whitney, M. Gomez, D. Sheff, T. E. Kreis, and I. Mellman, Cytoplasmic coat proteins involved in endosome function, Cell, vol.83, issue.5, pp.703-713, 1995.
DOI : 10.1016/0092-8674(95)90183-3

A. Wilde, C. Dempsey, and G. Banting, The tyrosine-containing internalization motif in the cytoplasmic domain of TGN38/41 lies within a nascent helix, J. Biol. Chem, vol.269, pp.7131-7136, 1994.

M. A. Williams and M. Fukuda, Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail, The Journal of Cell Biology, vol.111, issue.3, pp.955-966, 1990.
DOI : 10.1083/jcb.111.3.955

D. S. Wishart, B. D. Sykes, and F. M. Richards, Relationship between nuclear magnetic resonance chemical shift and protein secondary structure, Journal of Molecular Biology, vol.222, issue.2, pp.311-333, 1991.
DOI : 10.1016/0022-2836(91)90214-Q

D. E. Zwart, C. B. Brewer, J. Lazarovits, Y. I. Henis, and M. G. Roth, Degradation of Mutant Influenza Virus Hemagglutinins Is Influenced by Cytoplasmic Sequences Independent of Internalization Signals, Journal of Biological Chemistry, vol.271, issue.2, pp.907-917, 1996.
DOI : 10.1074/jbc.271.2.907