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Optimization of virulence functions through glucosylation of Shigella LPS.

Abstract : Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without compromising the protective properties of the LPS. Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00368071
Contributor : Cécile Roux <>
Submitted on : Friday, March 13, 2009 - 3:06:58 PM
Last modification on : Wednesday, July 29, 2020 - 11:10:48 AM

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Nicholas P. West, Philippe Sansonetti, Joëlle Mounier, Rachel M. Exley, Claude Parsot, et al.. Optimization of virulence functions through glucosylation of Shigella LPS.. Science, American Association for the Advancement of Science, 2005, 307 (5713), pp.1313-7. ⟨10.1126/science.1108472⟩. ⟨pasteur-00368071⟩

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