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Mutagenesis and molecular modeling reveal three key extracellular loops of the membrane receptor HasR that are involved in hemophore HasA binding.

Abstract : On the basis of the three-dimensional model of the heme/hemophore TonB-dependent outer membrane receptor HasR, mutants with six-residue deletions in the 11 putative extracellular loops were generated. Although all mutants continued to be active TonB-dependent heme transporters, mutations in three loops abolished hemophore HasA binding both in vivo and in vitro.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00366344
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Submitted on : Friday, March 6, 2009 - 3:32:19 PM
Last modification on : Monday, January 13, 2020 - 5:08:08 PM

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Clément Barjon, Karine Wecker, Nadia Izadi-Pruneyre, Philippe Delepelaire. Mutagenesis and molecular modeling reveal three key extracellular loops of the membrane receptor HasR that are involved in hemophore HasA binding.. Journal of Bacteriology, American Society for Microbiology, 2007, 189 (14), pp.5379-82. ⟨10.1128/JB.00251-07⟩. ⟨pasteur-00366344⟩

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