Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

Denise Guetard; Raffaella Greco; Minerva Cervantes Gonzalez; Susanna Celli; Anna Kostrzak; Pierre Langlade-Demoyen; Francesco Sala; Simon Wain-Hobson; Monica Sala

doi:10.1016/j.vaccine.2008.06.059

Journal articles

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

Denise Guetard ¹ Raffaella Greco ² Minerva Cervantes Gonzalez ¹ Susanna Celli ³ Anna Kostrzak ^{1, 4} Pierre Langlade-Demoyen ¹ Francesco Sala ² Simon Wain-Hobson ¹ Monica Sala ^{1, *}

* Corresponding author

1 Rétrovirologie Moléculaire

2 Department of Biology

3 Département d'Immunologie - Department of Immunology

4 Laboratory of Structural Genomics

Abstract : Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Immunology / Vaccinology

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Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

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Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

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