Skip to Main content Skip to Navigation
Journal articles

Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine.

Abstract : Human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV) spread via similar transmission pathways, and infection by HBV occurs in up to 32% of HIV-1 cases. Here, we describe the successful expression of novel recombinant HIV-1/HBV virus-like particles (VLPs) in Nicotiana tabacum and Arabidopsis thaliana. The production levels and quality of the recombinant VLPs were comparable in the two plants, showing that parameters intrinsic to the recombinant proteins determined their assembly into VLPs. These heterologous VLPs can be used in a bivalent anti-HIV-1/-HBV vaccine, administrated via ingestion of transgenic plants.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-00363393
Contributor : Mireille Gau <>
Submitted on : Monday, February 23, 2009 - 11:12:37 AM
Last modification on : Monday, January 13, 2020 - 5:08:10 PM

Identifiers

Collections

Citation

Raffaella Greco, Marie Michel, Denise Guetard, Minerva Cervantes-Gonzalez, Nilla Pelucchi, et al.. Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine.. Vaccine, Elsevier, 2007, 25 (49), pp.8228-40. ⟨10.1016/j.vaccine.2007.09.061⟩. ⟨pasteur-00363393⟩

Share

Metrics

Record views

169