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Journal articles
A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.
Christian A. J. Vosshenrich
1
Marcos E. García-Ojeda
1
Sandrine I. Samson-Villéger
1
Valerie Pasqualetto
2, 3
Laurence Enault
1
Odile Richard-Le Goff
1
Erwan Corcuff
1
Delphine Guy-Grand
1
Benedita Rocha
3
Ana Cumano
4
Lars Rogge
5
Sophie Ezine
3
James P. Di Santo
1, *
Christian A. J. Vosshenrich 1
Author IdHAL : christian-vosshenrich ORCID : https://orcid.org/0000-0002-4407-8649
Marcos E. García-Ojeda 1
Author
Sandrine I. Samson-Villéger 1
Author
Valerie Pasqualetto 2, 3
Author IdHAL : rcxpasqualv ORCID : https://orcid.org/0000-0002-9812-8701
Laurence Enault 1
Author
Odile Richard-Le Goff 1
Author
Erwan Corcuff 1
Author
Delphine Guy-Grand 1
Author
James P. Di Santo 1
Correspondent author
1
Cytokines et Développement Lymphoïde (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U668 (101, rue de Tolbiac, 75013 Paris - France)
2
UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
3
U591 - Differenciation Thymique et Physiologie des Lymphocytes T (Fac de Medecine Necker-Enfants Malades
156, Rue de Vaugirard
75730 PARIS CEDEX 15 - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR_S 591 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U591 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_S 591 (France)
4
Développement des Lymphocytes (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U668 (101, rue de Tolbiac, 75013 Paris - France)
5
Immunorégulation (Département d'Immunologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : URA1961 (France)
Abstract : Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127+ NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi) CD16- NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56+ CD16+ NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00362040
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, February 17, 2009 - 10:30:42 AM
Last modification on : Thursday, June 11, 2020 - 6:44:03 PM
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, February 17, 2009 - 10:30:42 AM
Last modification on : Thursday, June 11, 2020 - 6:44:03 PM
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- HAL Id : pasteur-00362040, version 1
- DOI : 10.1038/ni1395
- PUBMED : 17013389
Collections
UNIV-PARIS5 | CNRS | ATP-IMMUN | PASTEUR | USPC | UNIV-PARIS
Citation
Christian A. J. Vosshenrich, Marcos E. García-Ojeda, Sandrine I. Samson-Villéger, Valerie Pasqualetto, Laurence Enault, et al.. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.. Nature Immunology, Nature Publishing Group, 2006, 7 (11), pp.1217-24. ⟨10.1038/ni1395⟩. ⟨pasteur-00362040⟩
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