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A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.

Abstract : Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127+ NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi) CD16- NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56+ CD16+ NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00362040
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, February 17, 2009 - 10:30:42 AM
Last modification on : Thursday, June 11, 2020 - 6:44:03 PM

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Christian A. J. Vosshenrich, Marcos E. García-Ojeda, Sandrine I. Samson-Villéger, Valerie Pasqualetto, Laurence Enault, et al.. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.. Nature Immunology, Nature Publishing Group, 2006, 7 (11), pp.1217-24. ⟨10.1038/ni1395⟩. ⟨pasteur-00362040⟩

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