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T(H)1 cells control themselves by producing interleukin-10.

Abstract : Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00362024
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, February 17, 2009 - 10:17:50 AM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM

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Anne O'Garra, Paulo Vieira. T(H)1 cells control themselves by producing interleukin-10.. Nature Reviews Immunology, Nature Publishing Group, 2007, 7 (6), pp.425-8. ⟨10.1038/nri2097⟩. ⟨pasteur-00362024⟩

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