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Journal articles
Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior.
Cedric Auffray
1
Darin Fogg
1
Meriem Garfa
1
Gaelle Elain
1
Olivier Join-Lambert
2, 3
Samer Kayal
1, 2, 3
Sabine Sarnacki
2, 3
Ana Cumano
4
Gregoire Lauvau
5
Frederic Geissmann
1, 2, 3, *
Olivier Join-Lambert 2, 3
Author
Samer Kayal 1, 2, 3
Author
Sabine Sarnacki 2, 3
Author
Ana Cumano 4
Author
Gregoire Lauvau 5
Author
Frederic Geissmann 1, 2, 3
Correspondent author
1
Système des phagocytes mononucléés et immunopathologie (Hopital Necker Enfants Malades
149 rue de Sevres
75743 PARIS CEDEX 15 - France)
- UPD5 - Université Paris Descartes - Paris 5 : EA 219 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
2
UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
3
CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
4
Développement des Lymphocytes (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U668 (101, rue de Tolbiac, 75013 Paris - France)
5
Immunologie des Maladies Infectieuses Allergiques et Autoimmunes (Ipmc Sophia Antipolis 660, Route Des Lucioles 06560 VALBONNE CEDEX - France)
- UNS - Université Nice Sophia Antipolis (... - 2019) (Parc Valrose - BP 2135 - 06103 Nice cedex 2 - France)
- COMUE UCA - COMUE Université Côte d'Azur (2015 - 2019) (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : E344 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX(3)CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.
Document type :
Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00337698
Contributor : Marie-Christine Vougny <>
Submitted on : Friday, November 7, 2008 - 4:22:06 PM
Last modification on : Thursday, May 27, 2021 - 5:08:02 PM
Contributor : Marie-Christine Vougny <>
Submitted on : Friday, November 7, 2008 - 4:22:06 PM
Last modification on : Thursday, May 27, 2021 - 5:08:02 PM
Identifiers
- HAL Id : pasteur-00337698, version 1
- DOI : 10.1126/science.1142883
- PUBMED : 17673663
Collections
PASTEUR | UNIV-PARIS5 | UNICE | USPC | UNIV-COTEDAZUR | UNIV-PARIS
Citation
Cedric Auffray, Darin Fogg, Meriem Garfa, Gaelle Elain, Olivier Join-Lambert, et al.. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior.. Science, American Association for the Advancement of Science, 2007, 317 (5838), pp.666-70. ⟨10.1126/science.1142883⟩. ⟨pasteur-00337698⟩
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