Are hematopoietic stem cells generated in the placenta?

Aurelie Kieusseian (1) , Ana Cumano (1)

1 Département d'Immunologie - Department of Immunology

In this issue of Cell Stem Cell, the origin of multipotent hematopoietic cells present in the placenta has been assessed in Ncx1(-/-) embryos lacking a functional heart and circulation. Rhodes and colleagues (Rhodes et al., 2008) found lymphoid progenitors in the placenta, as well as in dorsal aorta and yolk sac and vitelline vessels, indicating that they arose in situ.

Domaines: Immunologie

Aurelie Kieusseian, Ana Cumano. Are hematopoietic stem cells generated in the placenta?. Cell Stem Cell, 2008, 2 (3), pp.197-8. ⟨10.1016/j.stem.2008.02.013⟩. ⟨pasteur-00336962⟩