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Phasing of the Triatoma virus diffraction data using a cryo-electron microscopy reconstruction.

Abstract : The blood-sucking reduviid bug Triatoma infestans, one of the most important vector of American human trypanosomiasis (Chagas disease) is infected by the Triatoma virus (TrV). TrV has been classified as a member of the Cripavirus genus (type cricket paralysis virus) in the Dicistroviridae family. This work presents the three-dimensional cryo-electron microscopy (cryo-EM) reconstruction of the TrV capsid at about 25 A resolution and its use as a template for phasing the available crystallographic data by the molecular replacement method. The main structural differences between the cryo-EM reconstruction of TrV and other two viruses, one from the same family, the cricket paralysis virus (CrPV) and the human rhinovirus 16 from the Picornaviridae family are presented and discussed.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00335426
Contributor : Mireille Gau <>
Submitted on : Wednesday, October 29, 2008 - 3:18:32 PM
Last modification on : Tuesday, October 6, 2020 - 4:12:02 PM

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Leandro F Estrozi, Emmanuelle Neumann, G. Squires, G. Rozas-Dennis, M. Costabel, et al.. Phasing of the Triatoma virus diffraction data using a cryo-electron microscopy reconstruction.. Virology, Elsevier, 2008, 375 (1), pp.85-93. ⟨10.1016/j.virol.2007.12.025⟩. ⟨pasteur-00335426⟩

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