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Resource competition as a mechanism for B cell homeostasis.

Abstract : Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.
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Contributor : Marie-Christine Vougny <>
Submitted on : Friday, October 10, 2008 - 2:13:29 PM
Last modification on : Monday, January 13, 2020 - 5:08:14 PM

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A. R. Mclean, M. M. Rosado, Fabien Agenes, R. Vasconcellos, Antonio A. Freitas. Resource competition as a mechanism for B cell homeostasis.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1997, 94 (11), pp.5792-7. ⟨10.1073/pnas.94.11.5792⟩. ⟨pasteur-00329067⟩



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