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Differential requirements for survival and proliferation of CD8 naïve or memory T cells.

Abstract : The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal na? and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Na? T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00327781
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, October 9, 2008 - 2:40:51 PM
Last modification on : Thursday, April 9, 2020 - 11:55:08 AM

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Corinne Tanchot, François A. Lemonnier, Béatrice Pérarnau, Antonio A. Freitas, Benedita Rocha. Differential requirements for survival and proliferation of CD8 naïve or memory T cells.. Science, American Association for the Advancement of Science, 1997, 276 (5321), pp.2057-62. ⟨10.1126/science.276.5321.2057⟩. ⟨pasteur-00327781⟩

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