HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Independent homeostatic regulation of B cell compartments.

Abstract : In the present study we used mice with a developmental arrest of B cell production to study the ability of a limited number of normal B cell precursors to populate peripheral B cell pools. In chimeras reconstituted with mixtures of bone marrow (BM) cells from normal and B cell-deficient donors, we show that the rate of BM B cell production is a constant function of the number of BM pre-B cells and is not modified by the peripheral B cell pool size, i.e. there is no feedback regulation of the central pre-B cell compartment by the number of mature B cells. We also show that the physiological number of peripheral B cells requires a minimum continuous input of newly formed cells, but is not determined by the number of B cell precursors. Chimeras with a threefold reduced rate of BM B cell production have normal numbers of peripheral B cells. Parabiosis between normal and B cell-deficient mice showed that the BM B cell production of one mouse suffices to replenish the B cell pool of three mice. Finally, we show that the compartment of activated IgM-secreting B cells is homeostatically autonomous since the number of cells it comprises is regulated independently of the size of the mature B cell pool. The results presented here support a model of the immune system in which the size of the different B cell compartments, i.e. pre-B, resting B and IgM-secreting, is autonomously regulated.
Document type :
Journal articles
Complete list of metadata

Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Wednesday, October 8, 2008 - 4:16:18 PM
Last modification on : Thursday, April 7, 2022 - 10:10:16 AM




Fabien Agenès, Maria Manuela Rosado, Antonio A. Freitas. Independent homeostatic regulation of B cell compartments.. European Journal of Immunology, Wiley-VCH Verlag, 1997, 27 (7), pp.1801-7. ⟨10.1002/eji.1830270731⟩. ⟨pasteur-00327535⟩



Record views