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Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation.

Abstract : Like their human counterparts, mouse plasmacytoid dendritic cells (pDCs) play a central role in innate immunity against viral infections, but their capacity to prime T cells in vivo remains unknown. We show here that virus-activated pDCs differentiate into antigen-presenting cells able to induce effector/memory CD8(+) T-cell responses in vivo against both epitopic peptides and endogenous antigen, whereas pDCs activated by synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG) acquire only the ability to recall antigen-experienced T-cell responses. We also show that immature pDCs are unable to induce effector or regulatory CD8(+) T-cell responses. Thus, murine pDCs take part in both innate and adaptive immune responses by directly priming naive CD8(+) T cells during viral infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00327333
Contributor : Marie-Christine Vougny <>
Submitted on : Wednesday, October 8, 2008 - 11:18:38 AM
Last modification on : Saturday, March 28, 2020 - 2:20:49 AM

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Géraldine Schlecht, Sylvie Garcia, Nicolas Escriou, Antonio A Freitas, Claude Leclerc, et al.. Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation.. Blood, American Society of Hematology, 2004, 104 (6), pp.1808-15. ⟨10.1182/blood-2004-02-0426⟩. ⟨pasteur-00327333⟩

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