Abstract : Nucleoside 2'-deoxyribosyltransferase (NDT) is used to synthesize unnatural 2'-deoxyribonucleosides, modified mostly on the heterocyclic base. Here we describe a strategy for improving 2,3-dideoxyribosyl(ddR) transfer activity of NDT by combining mutagenesis and in vivo selection in E. coli.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00325467 Contributor : Sylvie PochetConnect in order to contact the contributor Submitted on : Monday, September 29, 2008 - 2:26:20 PM Last modification on : Thursday, May 5, 2022 - 3:18:01 PM