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Expanding substrate specificity of nucleoside 2'-deoxyribosyltransferase.

Pierre-Alexandre Kaminski 1, * Laurence Dugué 1 Sylvie Pochet 1 
* Corresponding author
Abstract : Nucleoside 2'-deoxyribosyltransferase (NDT) is used to synthesize unnatural 2'-deoxyribonucleosides, modified mostly on the heterocyclic base. Here we describe a strategy for improving 2,3-dideoxyribosyl(ddR) transfer activity of NDT by combining mutagenesis and in vivo selection in E. coli.
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Submitted on : Monday, September 29, 2008 - 2:26:20 PM
Last modification on : Thursday, May 5, 2022 - 3:18:01 PM

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Pierre-Alexandre Kaminski, Laurence Dugué, Sylvie Pochet. Expanding substrate specificity of nucleoside 2'-deoxyribosyltransferase.. Nucleic Acids Symposium Series, 2008, 52, pp.495-6. ⟨10.1093/nass/nrn251⟩. ⟨pasteur-00325467⟩



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