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Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.

Abstract : Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.
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Contributor : Hélène Ribierre <>
Submitted on : Thursday, September 4, 2008 - 1:43:28 PM
Last modification on : Monday, January 13, 2020 - 5:08:10 PM

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Franck B. Riquet, Claire Blanchard, Sophie Jegouic, Jean Balanant, Sophie Guillot, et al.. Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.. Journal of Virology, American Society for Microbiology, 2008, 82 (17), pp.8927-32. ⟨10.1128/JVI.00239-08⟩. ⟨pasteur-00318592⟩

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