S. Bray, Notch signalling: a simple pathway becomes complex, Nature Reviews Molecular Cell Biology, vol.281, issue.9, pp.678-689, 2006.
DOI : 10.1016/S1534-5807(04)00097-8

I. Busseau, R. Diederich, T. Xu, and S. Artavanistsakonas, A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein, Genetics, vol.136, pp.585-596, 1994.

M. Cornell, D. Evans, R. Mann, M. Fostier, and M. Flasza, The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase, Genetics, vol.152, pp.567-576, 1999.

M. Fostier, D. Evans, S. Artavanis-tsakonas, and M. Baron, Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of Notch signaling, Genetics, vol.150, pp.1477-1485, 1998.

W. Perry, C. Hustad, D. Swing, O. Sullivan, T. Jenkins et al., The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice, Nature Genetics, vol.140, issue.2, pp.143-146, 1998.
DOI : 10.1074/jbc.270.52.30862

L. Matesic, D. Haines, N. Copeland, and N. Jenkins, Itch genetically interacts with Notch1 in a mouse autoimmune disease model, Human Molecular Genetics, vol.15, issue.24, pp.3485-3497, 2006.
DOI : 10.1093/hmg/ddl425

A. Marchese, C. Raiborg, F. Santini, J. Keen, and H. Stenmark, The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4, Developmental Cell, vol.5, issue.5, pp.709-722, 2003.
DOI : 10.1016/S1534-5807(03)00321-6

M. Rossi, R. Aqeilan, M. Neale, C. E. Salomoni, and P. , The E3 ubiquitin ligase Itch controls the protein stability of p63, Proceedings of the National Academy of Sciences, vol.103, issue.34, pp.12753-12758, 2006.
DOI : 10.1073/pnas.0603449103

M. Rossi, D. Laurenzi, V. Munarriz, E. Green, D. Liu et al., The ubiquitin???protein ligase Itch regulates p73 stability, The EMBO Journal, vol.19, issue.4, pp.836-848, 2005.
DOI : 10.1006/jmbi.2001.4572

F. Lallemand, S. Seo, N. Ferrand, M. Pessah, L. Hoste et al., AIP4 Restricts Transforming Growth Factor-?? Signaling through a Ubiquitination-independent Mechanism, Journal of Biological Chemistry, vol.280, issue.30, pp.27645-27653, 2005.
DOI : 10.1074/jbc.M500188200

M. Gao, T. Labuda, Y. Xia, E. Gallagher, and D. Fang, Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch, Science, vol.306, issue.5694, pp.271-275, 2004.
DOI : 10.1126/science.1099414

P. Chastagner, A. Israel, and C. Brou, Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains, EMBO reports, vol.18, issue.11, pp.1147-1153, 2006.
DOI : 10.1016/j.str.2005.07.015
URL : https://hal.archives-ouvertes.fr/pasteur-00162850

A. Angers, A. Ramjaun, and P. Mcpherson, The HECT Domain Ligase Itch Ubiquitinates Endophilin and Localizes to the trans-Golgi Network and Endosomal System, Journal of Biological Chemistry, vol.279, issue.12, pp.11471-11479, 2004.
DOI : 10.1074/jbc.M309934200

T. Wegierski, K. Hill, M. Schaefer, and G. Walz, The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels, The EMBO Journal, vol.372, issue.24, pp.5659-5669, 2006.
DOI : 10.1038/sj.emboj.7601429

C. Yang, W. Zhou, M. Jeon, D. Demydenko, and Y. Harada, Negative Regulation of the E3 Ubiquitin Ligase Itch via Fyn-Mediated Tyrosine Phosphorylation, Molecular Cell, vol.21, issue.1, pp.135-141, 2006.
DOI : 10.1016/j.molcel.2005.11.014

D. Fang and T. Kerppola, Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes, Proceedings of the National Academy of Sciences, vol.101, issue.41, pp.14782-14787, 2004.
DOI : 10.1073/pnas.0404445101
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522008

T. Sakata, H. Sakaguchi, L. Tsuda, A. Higashitani, and T. Aigaki, Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation, Current Biology, vol.14, issue.24, pp.2228-2236, 2004.
DOI : 10.1016/j.cub.2004.12.028

M. Wilkin, A. Carbery, M. Fostier, H. Aslam, and S. Mazaleyrat, Regulation of Notch Endosomal Sorting and Signaling by Drosophila Nedd4 Family Proteins, Current Biology, vol.14, issue.24, pp.2237-2244, 2004.
DOI : 10.1016/j.cub.2004.11.030

L. Qiu, C. Joazeiro, N. Fang, H. Wang, and C. Elly, Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase, Journal of Biological Chemistry, vol.275, issue.46, pp.35734-35737, 2000.
DOI : 10.1074/jbc.M007300200

M. Rand, L. Grimm, S. Artavanis-tsakonas, V. Patriub, and S. Blacklow, Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors, Molecular and Cellular Biology, vol.20, issue.5, pp.1825-1835, 2000.
DOI : 10.1128/MCB.20.5.1825-1835.2000
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85363/pdf

F. Logeat, C. Bessia, C. Brou, O. Lebail, and S. Jarriault, The Notch1 receptor is cleaved constitutively by a furin-like convertase, Proceedings of the National Academy of Sciences, vol.95, issue.14, pp.8108-8112, 1998.
DOI : 10.1073/pnas.95.14.8108

E. Schroeter, J. Kisslinger, and R. Kopan, Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain, Nature, vol.393, pp.382-386, 1998.

F. Huang, D. Kirkpatrick, X. Jiang, S. Gygi, and A. Sorkin, Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain, Molecular Cell, vol.21, issue.6, pp.737-748, 2006.
DOI : 10.1016/j.molcel.2006.02.018

M. Jennings, R. Blankley, M. Baron, A. Golovanov, and J. Avis, Specificity and Autoregulation of Notch Binding by Tandem WW Domains in Suppressor of Deltex, Journal of Biological Chemistry, vol.282, issue.39, pp.29032-29042, 2007.
DOI : 10.1074/jbc.M703453200

K. Moberg, S. Schelble, S. Burdick, and I. Hariharan, Mutations in erupted, the Drosophila Ortholog of Mammalian Tumor Susceptibility Gene 101, Elicit Non-Cell-Autonomous Overgrowth, Developmental Cell, vol.9, issue.5, pp.699-710, 2005.
DOI : 10.1016/j.devcel.2005.09.018

B. Thompson, J. Mathieu, H. Sung, E. Loeser, and P. Rorth, Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila, Developmental Cell, vol.9, issue.5, pp.711-720, 2005.
DOI : 10.1016/j.devcel.2005.09.020

T. Vaccari and D. Bilder, The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking, Developmental Cell, vol.9, issue.5, pp.687-698, 2005.
DOI : 10.1016/j.devcel.2005.09.019

A. Mukherjee, A. Veraksa, A. Bauer, C. Rosse, and J. Camonis, Regulation of Notch signalling by non-visual ??-arrestin, Nature Cell Biology, vol.152, issue.12, pp.1191-1201, 2005.
DOI : 10.1126/science.285.5434.1737

K. Longva, F. Blystad, E. Stang, A. Larsen, and L. Johannessen, Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies, The Journal of Cell Biology, vol.112, issue.5, pp.843-854, 2002.
DOI : 10.1074/jbc.274.44.31707

B. Jehn, I. Dittert, S. Beyer, K. Von-der-mark, and W. Bielke, c-Cbl Binding and Ubiquitin-dependent Lysosomal Degradation of Membrane-associated Notch1, Journal of Biological Chemistry, vol.277, issue.10, pp.8033-8040, 2002.
DOI : 10.1074/jbc.M108552200

F. Huang, L. Goh, and A. Sorkin, EGF receptor ubiquitination is not necessary for its internalization, Proceedings of the National Academy of Sciences, vol.104, issue.43, pp.16904-16909, 2007.
DOI : 10.1073/pnas.0707416104
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040475

K. Kumar, H. Barriere, C. Carbone, J. Liu, and G. Swaminathan, Site-specific ubiquitination exposes a linear motif to promote interferon-?? receptor endocytosis, The Journal of Cell Biology, vol.15, issue.5, pp.935-950, 2007.
DOI : 10.1073/pnas.94.17.9273

S. Bonni, H. Wang, C. Causing, P. Kavsak, and S. Stroschein, TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation, Nature Cell Biology, vol.3, issue.6, pp.587-595, 2001.
DOI : 10.1038/35078562

T. Ebisawa, M. Fukuchi, G. Murakami, T. Chiba, and K. Tanaka, Smurf1 Interacts with Transforming Growth Factor-beta Type I Receptor through Smad7 and Induces Receptor Degradation, Journal of Biological Chemistry, vol.276, issue.16, pp.12477-12480, 2001.
DOI : 10.1074/jbc.C100008200

P. Kavsak, R. Rasmussen, C. Causing, S. Bonni, and H. Zhu, Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGF?? Receptor for Degradation, Molecular Cell, vol.6, issue.6, pp.1365-1375, 2000.
DOI : 10.1016/S1097-2765(00)00134-9

K. Matsuno, R. Diederich, M. Go, and C. Blaumuller, Artavanis-Tsakonas S (1995) Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats, Development, vol.121, pp.2633-2644

M. Mcgill and C. Mcglade, Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain, Journal of Biological Chemistry, vol.278, issue.25, pp.23196-23203, 2003.
DOI : 10.1074/jbc.M302827200

D. Marcotullio, L. Ferretti, E. Greco, A. , D. Smaele et al., Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination, Nature Cell Biology, vol.131, issue.12, pp.1415-1423, 2006.
DOI : 10.1038/nm0598-619