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Regulation of allergy by Fc receptors.

Abstract : The aggregation of high-affinity IgE receptors (FcepsilonRI) on mast cells and basophils has long been known as the critical event that initiates allergic reactions. Monomeric IgE was recently found to induce a variety of effects when binding to FcepsilonRI. Upregulation of FcepsilonRI only requires binding, whereas other responses require FcepsilonRI aggregation. Interestingly, FcepsilonRI aggregation has recently been understood to generate a mixture of positive and negative intracellular signals. Mast cells and basophils also express low-affinity and, under specific conditions, high-affinity IgG receptors. When co-engaging these receptors with FcepsilonRI, IgG antibodies can amplify or dampen IgE-induced mast cell activation. On the basis of these findings, it has been proposed that FcRs can be used as targets and/or tools for new therapeutic approaches to allergies.
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Pierre Bruhns, Sophie Frémont, Marc Daëron. Regulation of allergy by Fc receptors.. Current Opinion in Immunology, Elsevier, 2005, 17 (6), pp.662-9. ⟨10.1016/j.coi.2005.09.012⟩. ⟨pasteur-00270046⟩

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