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Journal articles
On the origin of leprosy.
Marc Monot
1
Nadine Honoré
1
Thierry Garnier
1
Romulo Araoz
1
Jean-Yves Coppée
2
Céline Lacroix
2
Samba Sow
3
John S. Spencer
4
Richard W. Truman
5
Diana L. Williams
5
Robert Gelber
6
Marcos Virmond
7
Béatrice Flageul
8
Sang-Nae Cho
9
Baohong Ji
10
Alberto Paniz-Mondolfi
11
Jacinto Convit
11
Saroj Young
12
Paul E. Fine
12
Voahangy Rasolofo
13
Patrick J. Brennan
4
Stewart T Cole
1, *
*
Corresponding author
Marc Monot 1
Author IdHAL : marcmonot ORCID : https://orcid.org/0000-0003-0738-7335
Nadine Honoré 1
Author
Thierry Garnier 1
Author
Romulo Araoz 1
Author IdHAL : romulo-araoz ORCID : https://orcid.org/0000-0003-0435-0297
Richard W. Truman 5
Author
Diana L. Williams 5
Author
Robert Gelber 6
Author
Marcos Virmond 7
Author
Béatrice Flageul 8
Author
Sang-Nae Cho 9
Author
Baohong Ji 10
Author
Alberto Paniz-Mondolfi 11
Author
Patrick J. Brennan 4
Author
Stewart T Cole 1
Correspondent author
1
Génétique Moléculaire Bactérienne (28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
PF2 - Puces à ADN (Plate-Forme 2) (25-28 rue du Docteur Roux 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
3
Centre National d'Appui à la lutte Contre la Maladie (Bamako - Mali)
4
Department of Microbiology, Immunology and Pathology (Colorado State University, Fort Collins, Colorado - United States)
- University of Colorado [Boulder] (Boulder, Colorado 80309 - United States)
5
National Hansen's Disease Program (National Hansen's Disease Program, DHHS/HRSA/BPHC, Lousiana State University, Baton Rouge, Lousiana 70894 - United States)
- Lousiana State University (France)
6
Leonard Wood Memorial Center for Leprosy Research (Leonard Wood Memorial Center for Leprosy Research, Cebu - Philippines)
7
Instituto Lauro de Souza Lima (Instituto Lauro de Souza Lima, Bauru, São Paulo - Brazil)
- Instituto Lauro de Souza Lima (France)
8
Hôpital Saint-Louis (1, avenue Claude-Vellefaux 75475 PARIS Cedex 10 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
9
Yonsei University College of Medicine (Seoul - South Korea)
- Yonsei University College of Medicine (South Korea)
10
Service de Bactériologie-Hygiène Hospitalière [CHU Pitié-Salpêtrière] (47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
11
Instituto de Biomedicina [Caracas] (Caracas 1010, District fédéral, Venezuela - Venezuela)
- UCV - Universidad Central de Venezuela (Ciudad Universitaria, Los Chaguaramos Caracas, Venezuela - Venezuela)
12
LSHTM - London School of Hygiene and Tropical Medicine (Keppel Street
London
WC1E 7HT
- United Kingdom)
13
Institut Pasteur de Madagascar (B.P. 1274 Antananarivo - Madagascar)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
Abstract : Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.
Document type :
Journal articles
Complete list of metadatas
https://hal-pasteur.archives-ouvertes.fr/pasteur-00204117
Contributor : Marc Monot <>
Submitted on : Saturday, January 12, 2008 - 11:56:42 AM
Last modification on : Wednesday, December 30, 2020 - 2:58:03 AM
Long-term archiving on: : Friday, November 25, 2016 - 8:27:14 PM
Contributor : Marc Monot <>
Submitted on : Saturday, January 12, 2008 - 11:56:42 AM
Last modification on : Wednesday, December 30, 2020 - 2:58:03 AM
Long-term archiving on: : Friday, November 25, 2016 - 8:27:14 PM
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Identifiers
- HAL Id : pasteur-00204117, version 1
- DOI : 10.1126/science/1109759
- PUBMED : 15894530
Collections
PASTEUR | UNIV-PARIS7 | RIIP_MADAGASCAR | RIIP | USPC | UNIV-PARIS | SORBONNE-UNIVERSITE | SU-TI
Citation
Marc Monot, Nadine Honoré, Thierry Garnier, Romulo Araoz, Jean-Yves Coppée, et al.. On the origin of leprosy.. Science, American Association for the Advancement of Science, 2005, 308 (5724), pp.1040-2. ⟨10.1126/science/1109759⟩. ⟨pasteur-00204117⟩
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