Immunopotentiation of the antibody response against influenza HA with apoptotic bodies generated by rabies virus G-ERA protein-driven apoptosis. - Institut Pasteur Access content directly
Journal Articles Vaccine Year : 2005

Immunopotentiation of the antibody response against influenza HA with apoptotic bodies generated by rabies virus G-ERA protein-driven apoptosis.

F Mégret
  • Function : Author
C Préhaud
M Lafage
  • Function : Author
C Batejat
  • Function : Author
N Escriou
  • Function : Author
S Lay
  • Function : Author
M I Thoulouze
  • Function : Author
M Lafon
  • Function : Author

Abstract

Apoptosis is considered to be a way of eliminating unwanted cells without causing major inflammation. Nevertheless, several lines of evidence show that apoptotic cell-derived antigens can be strong immunogens. The rabies virus glycoprotein G-ERA is an apoptotic molecule. We tested the ability of G-ERA to potentiate a B cell response against an exogenous antigen (influenza hemagglutinin, HA). We found that co-expression of G-ERA and HA in apoptotic bodies increased both the primary and memory HA-specific immune responses. The immunopotentiation of G-ERA is apoptosis-mediated but not necrosis-mediated. Our data indicate that G-ERA-mediated apoptosis might be useful to improve the immunogenicity of live vaccines.

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Virology
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Dates and versions

pasteur-00194658 , version 1 (07-12-2007)

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F Mégret, C Préhaud, M Lafage, C Batejat, N Escriou, et al.. Immunopotentiation of the antibody response against influenza HA with apoptotic bodies generated by rabies virus G-ERA protein-driven apoptosis.. Vaccine, 2005, 23 (46-47), pp.5342-50. ⟨10.1016/j.vaccine.2005.06.027⟩. ⟨pasteur-00194658⟩

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