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Journal articles
Immunopotentiation of the antibody response against influenza HA with apoptotic bodies generated by rabies virus G-ERA protein-driven apoptosis.
Abstract : Apoptosis is considered to be a way of eliminating unwanted cells without causing major inflammation. Nevertheless, several lines of evidence show that apoptotic cell-derived antigens can be strong immunogens. The rabies virus glycoprotein G-ERA is an apoptotic molecule. We tested the ability of G-ERA to potentiate a B cell response against an exogenous antigen (influenza hemagglutinin, HA). We found that co-expression of G-ERA and HA in apoptotic bodies increased both the primary and memory HA-specific immune responses. The immunopotentiation of G-ERA is apoptosis-mediated but not necrosis-mediated. Our data indicate that G-ERA-mediated apoptosis might be useful to improve the immunogenicity of live vaccines.
Cited literature [44 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00194658
Contributor : Corinne Baran Connect in order to contact the contributor
Submitted on : Friday, December 7, 2007 - 10:24:07 AM
Last modification on : Tuesday, November 9, 2021 - 5:02:02 PM
Long-term archiving on: : Monday, April 12, 2010 - 6:31:32 AM
Contributor : Corinne Baran Connect in order to contact the contributor
Submitted on : Friday, December 7, 2007 - 10:24:07 AM
Last modification on : Tuesday, November 9, 2021 - 5:02:02 PM
Long-term archiving on: : Monday, April 12, 2010 - 6:31:32 AM
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Hallmegretvaccine2005.pdf
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