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Apoptosis inversely correlates with rabies virus neurotropism.

Abstract : We report that non-neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase-dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat-vect), but also a caspase-independent pathway. Cell redistribution of the apoptosis-inducing factor (AIF) was observed in Jurkat-vect infected with RV vaccine strain. Bcl-2 overproduction in Jurkat T cells (Jurkat-Bcl-2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.
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Submitted on : Thursday, September 24, 2020 - 9:24:59 AM
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Maria-Isabel Thoulouze, Mireille Lafage, Victor J Yuste, Guido Kroemer, Santos A Susin, et al.. Apoptosis inversely correlates with rabies virus neurotropism.. Annals of the New York Academy of Sciences, Wiley, 2003, 1010, pp.598-603. ⟨10.1196/annals.1299.112⟩. ⟨pasteur-00193959⟩



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