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Journal articles
Apoptosis inversely correlates with rabies virus neurotropism.
Abstract : We report that non-neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase-dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat-vect), but also a caspase-independent pathway. Cell redistribution of the apoptosis-inducing factor (AIF) was observed in Jurkat-vect infected with RV vaccine strain. Bcl-2 overproduction in Jurkat T cells (Jurkat-Bcl-2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.
Cited literature [4 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00193959
Contributor : Marie-Dominique Aytac Connect in order to contact the contributor
Submitted on : Thursday, September 24, 2020 - 9:24:59 AM
Last modification on : Monday, November 22, 2021 - 11:34:03 AM
Contributor : Marie-Dominique Aytac Connect in order to contact the contributor
Submitted on : Thursday, September 24, 2020 - 9:24:59 AM
Last modification on : Monday, November 22, 2021 - 11:34:03 AM
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