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A variant in the CD209 promoter is associated with severity of dengue disease.

Abstract : Dengue fever and dengue hemorrhagic fever are mosquito-borne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 x 10(-7)) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 x 10(-6)). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.
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Contributor : Hélène Ribierre Connect in order to contact the contributor
Submitted on : Monday, October 8, 2007 - 10:08:33 AM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM

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Anavaj Sakuntabhai, Chairat Turbpaiboon, Isabelle Casadémont, Ampaiwan Chuansumrit, Tassanee Lowhnoo, et al.. A variant in the CD209 promoter is associated with severity of dengue disease.. Nature Genetics, 2005, 37 (5), pp.507-13. ⟨10.1038/ng1550⟩. ⟨pasteur-00177402⟩



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