Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life.

N. Guiso (1) , E. Njamkepo (1) , F. Vié Le Sage , F. Zepp (2) , C. U. Meyer , V. Abitbol (3) , N. Clyti (3) , S. Chevallier (3)

1 Prévention et thérapie moléculaires des maladies humaines
2 Paediatric Immunology
3 Laboratoire GlaxoSmithKline [ Marly-le-Roi]

Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Environmental Sciences; Biodiversity and Ecology; Environmental Sciences; Environmental and Society; Environmental Sciences; Global Changes

N. Guiso, E. Njamkepo, F. Vié Le Sage, F. Zepp, C. U. Meyer, et al.. Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life.. Vaccine, 2007, 25 (8), pp.1390-7. ⟨10.1016/j.vaccine.2006.10.048⟩. ⟨pasteur-00169340⟩