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Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life.

Abstract : Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00169340
Contributor : Laurence Langlais <>
Submitted on : Monday, September 3, 2007 - 2:21:40 PM
Last modification on : Thursday, June 18, 2020 - 6:14:02 PM

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N. Guiso, E. Njamkepo, F. Vié Le Sage, F. Zepp, C. U. Meyer, et al.. Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life.. Vaccine, Elsevier, 2007, 25 (8), pp.1390-7. ⟨10.1016/j.vaccine.2006.10.048⟩. ⟨pasteur-00169340⟩

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