Pertussis in Argentina and France.

Valérie Caro (1, 2) , Valérie Bouchez (1, 2) , Nicole Guiso (1, 2) , Blanca Gatti (3) , Maria Rosa Agosti (4) , Silvia E Gonzàlez Ayala (4)

1 CNR - Centre National de Référence de la Coqueluche et autres bordetelloses
2 Prévention et thérapie moléculaires des maladies humaines
3 Laboratorio de Microbiología
4 Servicio Enfermedades Infecciosas

We have studied the epidemiology of pertussis in two countries, Argentina and France, which have similar histories of long-term mass vaccination with a whole-cell vaccine. Both countries display a comparable epidemiology, with an increase of the incidence of the disease in non-vaccinated newborns. We used pulsed-field gel electrophoresis (PFGE) analysis and genotyping to compare Bordetella pertussis clinical isolates recovered in Argentina and France in 2001-2004. The majority of the isolates harbors prn2 allele and belongs to PFGE IVbeta group. Isolates were found to be very similar genetically suggesting a common evolution of the disease in these two countries using the same vaccine.

Domaines: Maladies infectieuses; Biodiversité et Ecologie; Environnement et Société; Milieux et Changements globaux

Valérie Caro, Valérie Bouchez, Nicole Guiso, Blanca Gatti, Maria Rosa Agosti, et al.. Pertussis in Argentina and France.. Vaccine, 2007, 25 (22), pp.4335-9. ⟨10.1016/j.vaccine.2006.08.024⟩. ⟨pasteur-00169332⟩