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A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.

Abstract : A cDNA vaccine (pVax1/pet-neu) was designed to encode 12 different Her-2/ErbB-2-derived, HLA-A*0201-restricted dominant and high-affinity heteroclitic cryptic epitopes. Vaccination with pVax1/pet-neu triggered multiple and ErbB-2-specific CTL responses in HLA-A*0201 transgenic HHD mice and in HLA-A*0201 healthy donors in vitro. Human and murine CTL specific for each one of the 12 ErbB-2 peptides recognized in vitro both human and murine tumor cells overexpressing endogenous ErbB-2. Furthermore, vaccination of HHD mice with pVax1/pet-neu significantly delayed the in vivo growth of challenged ErbB-2-expressing tumor (EL4/HHD/neu murine thymoma) more actively when compared with vaccination with the empty vector (pVax1) or vehicle alone. These data indicate that the pVax1/pet-neu cDNA vaccine coding for a poly-ErbB-2 epitope is able to generate simultaneous ErbB-2-specific antitumor responses against dominant and cryptic multiple epitopes.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00167482
Contributor : François Lemonnier <>
Submitted on : Tuesday, August 21, 2007 - 9:41:47 AM
Last modification on : Wednesday, October 14, 2020 - 3:45:48 AM

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Antonio Scardino, Maurizio Alimandi, Pierpaolo Correale, Steven G Smith, Roberto Bei, et al.. A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.. Cancer Research, American Association for Cancer Research, 2007, 67 (14), pp.7028-36. ⟨10.1158/0008-5472.CAN-06-3998⟩. ⟨pasteur-00167482⟩

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