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Article Dans Une Revue Tetrahedron Letters Année : 1991

New fluorescent and photoactivable analogs acting on nucleotide binding enzymes

Résumé

We describe a seven-step synthesis of 8-azido-3′-O-anthraniloyl-2′dADP and 2′dATP from 8-azido-2′deoxyadenosine. These compounds can be used as fluorescent and photoactivable probes for the nucleotide-binding site of kinases or cyclases. These two analogs of ADP and ATP were synthesized and used as fluorescent and photoactivable probes for the nucleotide binding site of bacterial adenylate cyclase.

Dates et versions

pasteur-00167097 , version 1 (14-08-2007)

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Robert S. Sarfati, Abdelkader Namane, Hélène Munier, Octavian Barzu. New fluorescent and photoactivable analogs acting on nucleotide binding enzymes. Tetrahedron Letters, 1991, 32 (36), pp.4699-4702. ⟨10.1016/S0040-4039(00)92285-8⟩. ⟨pasteur-00167097⟩

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