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New fluorescent and photoactivable analogs acting on nucleotide binding enzymes

Abstract : We describe a seven-step synthesis of 8-azido-3′-O-anthraniloyl-2′dADP and 2′dATP from 8-azido-2′deoxyadenosine. These compounds can be used as fluorescent and photoactivable probes for the nucleotide-binding site of kinases or cyclases. These two analogs of ADP and ATP were synthesized and used as fluorescent and photoactivable probes for the nucleotide binding site of bacterial adenylate cyclase.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00167097
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Submitted on : Tuesday, August 14, 2007 - 4:35:46 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:52 PM

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Robert S. Sarfati, Abdelkader Namane, Hélène Munier, Octavian Barzu. New fluorescent and photoactivable analogs acting on nucleotide binding enzymes. Tetrahedron Letters, Elsevier, 1991, 32 (36), pp.4699-4702. ⟨10.1016/S0040-4039(00)92285-8⟩. ⟨pasteur-00167097⟩

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