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New fluorescent and photoactivable analogs acting on nucleotide binding enzymes

Robert S. Sarfati 1 Abdelkader Namane 1 Hélène Munier 2 Octavian Barzu 2
1 UCO - Chimie Organique
2 Biochimie des Régulations Cellulaires
Abstract : We describe a seven-step synthesis of 8-azido-3′-O-anthraniloyl-2′dADP and 2′dATP from 8-azido-2′deoxyadenosine. These compounds can be used as fluorescent and photoactivable probes for the nucleotide-binding site of kinases or cyclases. These two analogs of ADP and ATP were synthesized and used as fluorescent and photoactivable probes for the nucleotide binding site of bacterial adenylate cyclase.
Keywords : (nucleotide analogs / fluorescent and photoactivable derivatives ATP-dependent enzymes 8-azido-3′-O-anthraniloyl derivatives of 2′dATP and 2′dADP
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00167097
Contributor : Hélène Munier-Lehmann <>
Submitted on : Tuesday, August 14, 2007 - 4:35:46 PM
Last modification on : Tuesday, June 9, 2020 - 12:36:05 PM

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Robert S. Sarfati, Abdelkader Namane, Hélène Munier, Octavian Barzu. New fluorescent and photoactivable analogs acting on nucleotide binding enzymes. Tetrahedron Letters, Elsevier, 1991, 32 (36), pp.4699-4702. ⟨10.1016/S0040-4039(00)92285-8⟩. ⟨pasteur-00167097⟩

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