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Journal articles
Synthesis of alpha and beta-glycopyranosyl-serine derivatives by enzymic transglycosylation.
Abstract : The transglycosylation from raffinose and lactose to Aloc-Ser-OMe is catalyzed respectively by alpha and beta galactosidases. Transglycosylation from cellobiose has been achieved with beta-glucosidase. The simplicity of the enzymatic synthesis, the stereospecificity of the condensations in one-pot reactions and the ease of purification give the method value for large scale preparation of beta-linked derivatives. The protective groups of the serine residue can be cleaved under mild conditions: the ester group has been removed quantitatively by papain catalyzed hydrolysis and the Aloc group by a Pd (0) hydrostannolytic cleavage.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00167058
Contributor : Sylvie Bay Connect in order to contact the contributor
Submitted on : Tuesday, August 14, 2007 - 2:24:49 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:52 PM
Contributor : Sylvie Bay Connect in order to contact the contributor
Submitted on : Tuesday, August 14, 2007 - 2:24:49 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:52 PM