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Journal articles
Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.
Abstract : The susceptibility of phenotypically CCR5-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166869
Contributor : Françoise Baleux Connect in order to contact the contributor
Submitted on : Friday, August 10, 2007 - 4:31:31 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:51 PM
Contributor : Françoise Baleux Connect in order to contact the contributor
Submitted on : Friday, August 10, 2007 - 4:31:31 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:51 PM