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Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.

Abstract : The susceptibility of phenotypically CCR5-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166869
Contributor : Françoise Baleux <>
Submitted on : Friday, August 10, 2007 - 4:31:31 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM

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  • HAL Id : pasteur-00166869, version 1
  • PUBMED : 12441808

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Chantal Chanel, Isabelle Staropoli, Francoise Baleux, Ali Amara, Agustin Valenzuela-Fernandez, et al.. Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.. AIDS, Lippincott, Williams & Wilkins, 2002, 16 (17), pp.2337-40. ⟨pasteur-00166869⟩

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