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Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

Abstract : Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166843
Contributor : Sylvie Bay <>
Submitted on : Friday, August 10, 2007 - 2:36:17 PM
Last modification on : Wednesday, June 17, 2020 - 6:18:02 PM

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Sylvie Bay, Valérie Huteau, Maria-Leticia Zarantonelli, René Pires, Joël Ughetto-Monfrin, et al.. Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.. Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (16), pp.3916-9. ⟨10.1021/jm040783p⟩. ⟨pasteur-00166843⟩

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