Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

Sylvie Bay (1) , Valérie Huteau (1) , Maria-Leticia Zarantonelli (2) , René Pires (2) , Joël Ughetto-Monfrin (1) , Muhamed-Kheir Taha (2) , Patrick England (3) , Pierre Lafaye (4)

1 Chimie Organique
2 Neisseria
3 Biophysique des Macromolécules et de leurs Interactions
4 Génétique et Biochimie du Développement

Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.

Sylvie Bay, Valérie Huteau, Maria-Leticia Zarantonelli, René Pires, Joël Ughetto-Monfrin, et al.. Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.. Journal of Medicinal Chemistry, 2004, 47 (16), pp.3916-9. ⟨10.1021/jm040783p⟩. ⟨pasteur-00166843⟩