Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections. - Institut Pasteur Access content directly
Journal Articles Journal of Medicinal Chemistry Year : 2004

Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

Sylvie Bay
  • Function : Author
Valérie Huteau
  • Function : Author
René Pires
  • Function : Author
Muhamed-Kheir Taha
Pierre Lafaye

Abstract

Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.

Dates and versions

pasteur-00166843 , version 1 (10-08-2007)

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Sylvie Bay, Valérie Huteau, Maria-Leticia Zarantonelli, René Pires, Joël Ughetto-Monfrin, et al.. Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.. Journal of Medicinal Chemistry, 2004, 47 (16), pp.3916-9. ⟨10.1021/jm040783p⟩. ⟨pasteur-00166843⟩

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