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Journal articles
Human antibodies to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) exhibit a highly skewed, peptide-specific light chain distribution.
Abstract : Antibodies to polymorphic block 2 of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) present a paradoxical association with acquired protection against clinical malaria, while showing restricted and fixed specificity, reminiscent of antigenic sin. We report here that these antibodies present a highly imbalanced, peptide-specific light chain distribution. This was not observed with several other parasite-derived peptides or antigens. These data point to a skewed immune response to MSP-1 block 2 that is constrained both in specificity and chain usage. This is the first report of a biased response to polymorphic epitopes of a surface antigen in malaria parasites.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166674
Contributor : Françoise Baleux Connect in order to contact the contributor
Submitted on : Wednesday, August 8, 2007 - 1:53:22 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:51 PM
Contributor : Françoise Baleux Connect in order to contact the contributor
Submitted on : Wednesday, August 8, 2007 - 1:53:22 PM
Last modification on : Tuesday, October 19, 2021 - 10:25:51 PM