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Human antibodies to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) exhibit a highly skewed, peptide-specific light chain distribution.

Abstract : Antibodies to polymorphic block 2 of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) present a paradoxical association with acquired protection against clinical malaria, while showing restricted and fixed specificity, reminiscent of antigenic sin. We report here that these antibodies present a highly imbalanced, peptide-specific light chain distribution. This was not observed with several other parasite-derived peptides or antigens. These data point to a skewed immune response to MSP-1 block 2 that is constrained both in specificity and chain usage. This is the first report of a biased response to polymorphic epitopes of a surface antigen in malaria parasites.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166674
Contributor : Françoise Baleux <>
Submitted on : Wednesday, August 8, 2007 - 1:53:22 PM
Last modification on : Monday, January 13, 2020 - 5:08:08 PM

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Hélène Jouin, Olivier Garraud, Shirley Longacre, Françoise Baleux, Odile Mercereau-Puijalon, et al.. Human antibodies to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) exhibit a highly skewed, peptide-specific light chain distribution.. Immunology and Cell Biology, Nature Publishing Group, 2005, 83 (4), pp.392-5. ⟨10.1111/j.1440-1711.2005.01343.x⟩. ⟨pasteur-00166674⟩

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