Skip to Main content Skip to Navigation
Journal articles

Prions: protein only or something more? Overview of potential prion cofactors.

Abstract : Transmissible spongiform encephalopathies (TSEs) in humans and animals are attributed to protein-only infectious agents, called prions. Prions have been proposed to arise from the conformational conversion of the cellular protein PrP(C) into a misfolded form (e.g., PrP(Sc) for scrapie), which precipitates into aggregates and fibrils. It has been proposed that the conversion process is triggered by the interaction of the infectious form (PrP(Sc)) with the cellular form (PrP(C)) or might result from a mutation in the gene for PrP(C). However, until recently, all efforts to reproduce this process in vitro had failed, suggesting that host factors are necessary for prion replication. In this review we discuss recent findings such as the cellular factors that might be involved in the conformational conversion of prion proteins and the potential mechanisms by which they could operate.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-00166612
Contributor : Christiane Goisnard <>
Submitted on : Tuesday, August 7, 2007 - 4:42:38 PM
Last modification on : Wednesday, October 14, 2020 - 3:46:45 AM

Links full text

Identifiers

Collections

Citation

Carlo Fasano, Vincenza Campana, Chiara Zurzolo. Prions: protein only or something more? Overview of potential prion cofactors.. Journal of Molecular Neuroscience, Humana Press, 2006, 29 (3), pp.195-214. ⟨10.1385/JMN:29:3:195⟩. ⟨pasteur-00166612⟩

Share

Metrics

Record views

194