Interleukin-2: inception, impact, and implications, Science, vol.240, issue.4856, p.1169, 1988. ,
DOI : 10.1126/science.3131876
Interleukin 2 and its receptors: recent advances and new immunological functions, Immunology Today, vol.17, issue.10, p.481, 1996. ,
DOI : 10.1016/0167-5699(96)10057-C
lnterleukin-2 programs mouse ???? T lymphocytes for apoptosis, Nature, vol.353, issue.6347, p.858, 1991. ,
DOI : 10.1038/353858a0
Biochemical Mechanisms of IL-2???Regulated Fas-Mediated T Cell Apoptosis, Immunity, vol.8, issue.5, p.615, 1998. ,
DOI : 10.1016/S1074-7613(00)80566-X
Lymphoadenopathy in IL-2-Deficient Mice: Further Characterization and Overexpression of the Antiapoptotic Molecule Cellular FLIP, The Journal of Immunology, vol.169, issue.7, p.3644, 2002. ,
DOI : 10.4049/jimmunol.169.7.3644
The main function of IL-2 is to promote the development of T regulatory cells, Journal of Leukocyte Biology, vol.74, issue.6, 2003. ,
DOI : 10.1189/jlb.0603272
A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells, J. Immunol, vol.126, p.1393, 1981. ,
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor Interleukin 2 high-affinity receptor expression requires two distinct binding proteins, Nature J. Exp. Med, vol.311, issue.165, p.626223, 1984. ,
Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's, Science, vol.244, issue.4904, p.551, 1989. ,
DOI : 10.1126/science.2785715
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies., Proc. Natl Acad. Sci. USA, 1982. ,
DOI : 10.1073/pnas.86.6.1982
Cloning of the gamma chain of the human IL-2 receptor, Science, vol.257, issue.5068, p.379, 1992. ,
DOI : 10.1126/science.1631559
Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor alpha, beta and gamma chain expression for T cell growth, Biochem. Biophys. Res. Commun. Eur. J. Immunol, vol.193, issue.26, p.356201, 1993. ,
lnterleukin-2 Receptor Signaling Mechanisms, Adv. Immunol, vol.61, p.147, 1996. ,
DOI : 10.1016/S0065-2776(08)60867-6
Recent advances in the understanding of interleukin-2 signal transduction, Journal of Clinical Immunology, vol.18, issue.5, p.307, 1998. ,
DOI : 10.1023/A:1023223614407
JAKS AND STATS: Biological Implications, Annual Review of Immunology, vol.16, issue.1, p.293, 1998. ,
DOI : 10.1146/annurev.immunol.16.1.293
The role of Stat5a and Stat5b in signaling by IL-2 family cytokines, Oncogene, vol.19, issue.21, p.2566, 2000. ,
DOI : 10.1038/sj.onc.1203523
Alternate signalling pathways from the interleukin-2 receptor, Cytokine & Growth Factor Reviews, vol.13, issue.1, p.27, 2002. ,
DOI : 10.1016/S1359-6101(01)00023-5
Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2, Journal of Experimental Medicine, vol.163, issue.2, p.270, 1986. ,
DOI : 10.1084/jem.163.2.270
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice, J. Immunol, vol.153, p.5373, 1994. ,
dendritic epidermal cells in transgenic mice, International Immunology, vol.7, issue.9, p.1441, 1995. ,
DOI : 10.1093/intimm/7.9.1441
Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines, Science, vol.288, issue.5466, p.675, 2000. ,
DOI : 10.1126/science.288.5466.675
IL-2 receptor alpha-chain expression is independently regulated in primary and secondary lymphoid organs, J. Immunol, vol.161, 1977. ,
CDK inhibitors: positive and negative regulators of G1-phase progression, Genes & Development, vol.13, issue.12, p.1501, 1999. ,
DOI : 10.1101/gad.13.12.1501
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol. 13:65 Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line, Eur. J. Immunol, vol.29, issue.15, p.723, 1985. ,
Interleukin 2 upregulates expression of its receptor on a T cell clone Interleukin 2 regulates its own receptors, Proc. Natl Acad. Sci. USA 82, p.1575864, 1985. ,
Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene., Proc. Natl Acad. Sci. USA 82, p.4230, 1985. ,
DOI : 10.1073/pnas.82.12.4230
Expression of the IL-2 receptor ?? chain on various populations in human peripheral blood, International Immunology, vol.6, issue.8, p.1273, 1994. ,
DOI : 10.1093/intimm/6.8.1273
Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells, Journal of Experimental Medicine, vol.180, issue.1, p.241, 1994. ,
DOI : 10.1084/jem.180.1.241
Unstimulated Human CD4 Lymphocytes Express a Cytoplasmic Immature Form of the Common Cytokine Receptor ??-Chain, The Journal of Immunology, vol.167, issue.1, p.344, 2001. ,
DOI : 10.4049/jimmunol.167.1.344
Ligand-induced autoregulation of IL-2 receptor ?? chain expression in murine T cell lines, International Immunology, vol.8, issue.10, p.1521, 1996. ,
DOI : 10.1093/intimm/8.10.1521
High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways, Cytokine, vol.5, issue.4, p.362, 1993. ,
DOI : 10.1016/1043-4666(93)90069-H
IL-2-dependent expression of genes involved in cytoskeleton organization, oncogene regulation, and transcriptional control, J. Immunol, vol.162, p.3280, 1999. ,
DNA array analysis of interleukin-2-regulated immediate/early genes Analysis of gamma c-family cytokine target genes. Identification of dualspecificity phosphatase 5 (DUSP5) as a regulator of mitogenactivated protein kinase activity in interleukin-2 signaling, Med. Immunol. J. Biol. Chem, vol.1, issue.278, p.5205, 2002. ,
Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells, The Journal of Immunology, vol.166, issue.3, p.1675, 2001. ,
DOI : 10.4049/jimmunol.166.3.1675
T helper cells, IL-2 and the generation of cytotoxic T-cell responses, Trends in Immunology, vol.23, issue.10, p.465, 2002. ,
DOI : 10.1016/S1471-4906(02)02308-6
Cutting Edge: Antigen-Independent CD8 T Cell Proliferation, The Journal of Immunology, vol.166, issue.10, p.5864, 2001. ,
DOI : 10.4049/jimmunol.166.10.5864
Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses, The Journal of Immunology, vol.168, issue.4, p.1528, 2002. ,
DOI : 10.4049/jimmunol.168.4.1528
Constitutive Expression of a Chimeric Receptor That Delivers IL-2/IL-15 Signals Allows Antigen-Independent Proliferation of CD8+CD44high But Not Other T Cells, The Journal of Immunology, vol.164, issue.11, p.5659, 2000. ,
DOI : 10.4049/jimmunol.164.11.5659
IL-2-Activated CD8(+)CD44(high) cells express both adaptive and innate immune system receptors and demonstrate specificity for syngeneic tumor cells Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer, Regulation and control of IL-2 responsiveness 1101, pp.3442-471485, 1985. ,
Controlled Trial of Interleukin-2 Infusions in Patients Infected with the Human Immunodeficiency Virus, New England Journal of Medicine, vol.335, issue.18, p.1350, 1996. ,
DOI : 10.1056/NEJM199610313351803
Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity., Proc. Natl Acad. Sci. USA 93, p.10405, 1996. ,
DOI : 10.1073/pnas.93.19.10405
Immunologic and Virologic Effects of Subcutaneous Interleukin 2 in Combination With Antiretroviral Therapy, JAMA, vol.284, issue.2, p.183, 2000. ,
DOI : 10.1001/jama.284.2.183
Rapid Effect of Interleukin???2 Therapy in Human Immunodeficiency Virus???Infected Patients whose CD4 Cell Counts Increase Only Slightly in Response to Combined Antiretroviral Treatment, The Journal of Infectious Diseases, vol.183, issue.5, p.730, 2001. ,
DOI : 10.1086/318824
Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4, CD25(+) T cells, p.2159, 2002. ,
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo, Nature Medicine, vol.9, issue.5, p.540, 2003. ,
DOI : 10.1038/nm866